Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Primary investigator left institution
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Three different antibiotics are used to prevent infection in case of neurosurgery - this study examines to which extent the antibiotics penetrate from the blood to the cerebrospinal fluid (surrounding the brain).
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vancomycin | Active Comparator | Vancomycin is administered intravenously and subsequently measured in cerebrospinal fluid sample |
|
| Teicoplanin | Active Comparator | Teicoplanin is administered intravenously and subsequently measured in cerebrospinal fluid sample |
|
| Linezolid | Active Comparator | Linezolid is administered intravenously and subsequently measured in cerebrospinal fluid sample |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vancomycin | Drug | Vancomycin is administered intravenously and subsequently measured in cerebrospinal fluid sample |
|
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of antibiotics in cerebrospinal fluid | Concentration in CSF past i.v. injection | 1, 2, 4, 6, 12 hours |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D014640 | Vancomycin |
| D017334 | Teicoplanin |
| D000069349 | Linezolid |
| ID | Term |
|---|---|
| D006020 | Glycopeptides |
| D006001 | Glycoconjugates |
| D002241 | Carbohydrates |
| D010455 | Peptides |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Teicoplanin | Drug | Teicoplanin is administered intravenously and subsequently measured in cerebrospinal fluid sample |
|
| Linezolid | Drug | Linezolid is administered intravenously and subsequently measured in cerebrospinal fluid sample |
|
| D000602 |
| Amino Acids, Peptides, and Proteins |
| D000077427 | Lipoglycopeptides |
| D000081 | Acetamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000085 | Acetates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D023303 | Oxazolidinones |
| D010080 | Oxazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |