Study of Antibiotics in Cerebrospinal Fluid Following Intravenous Injection

Antibiotics in Cerebrospinal Fluid Following Intravenous Injection

Three different antibiotics are used to prevent infection in case of neurosurgery - this study examines to which extent the antibiotics penetrate from the blood to the cerebrospinal fluid (surrounding the brain).

Inclusion Criteria:

• Over 18 years old
• Already having an external CSF drain
• Scheduled for neurosurgery requiring antibiotic prophylaxis (most commonly placement of an internal drain ("shunt")

Exclusion Criteria:

• Infection or colonization requiring other than standard prophylactic antibiotics