Xylitol Versus Saline in Chronic Sinusitis

Randomized Controlled Trial of Xylitol Versus Saline Rinse For Chronic Sinusitis

Is a xylitol nasal rinse better or worse than saline on patient satisfaction.

In this pilot study, the investigators plan to compare the efficacy of twice daily xylitol nasal rinse with saline rinse which is the current standard, on outcomes such as quality of life and exacerbations.

We now have two arms to this study.

Group I: Immunocompetent subjects with chronic rhinosinusitis

Inclusion Criteria:

• 56 Adult subjects (18 or older) presenting to the ENT(ears, nose, throat) clinics who meet the diagnosis of chronic rhinosinusitis (CRS). Definition of CRS: Presence of at least 2 of the following 4 signs/symptoms for 12 weeks or longer despite medical management:

  • Anterior and/or posterior mucopurulent drainage
  • Nasal obstruction
  • Facial pain, pressure, and/or fullness
  • Decreased sense of smell

• In addition, objective evidence of sinus mucosal disease must be demonstrated on sinus CT imaging or direct endoscopic examination.

Exclusion Criteria:

• Cystic fibrosis
• Fungal sinusitis
• Immunocompromised status (use of long term oral steroids (> 30 days), AIDS, active malignancy or chemotherapy)
• Known Ciliary disorders
• Sinonasal tumors
• Pregnancy

Group 2: CRS with antibody deficiency

• 56 Adult subjects (18 or older) presenting to the Allergy clinic who meet the diagnosis of chronic rhinosinusitis (CRS). Definition of CRS: Presence of at least 2 of the following 4 signs/symptoms for 12 weeks or longer despite medical management:

  • Anterior and/or posterior mucopurulent drainage
  • Nasal obstruction
  • Facial pain, pressure, and/or fullness
  • Decreased sense of smell

• In addition, objective evidence of sinus mucosal disease must be demonstrated on sinus CT imaging or direct endoscopic examination.

Exclusion criteria:

Cystic Fibrosis Sinonasal tumors Pregnancy