The purpose of this study was to investigate a possible response to nalbuphine (Nubian) and morphine with traditional Chinese herbs in healthy volunteers.

This study is a single center and open-label design to investigate the pharmacokinetic properties of Nubian, Nubian traditional Chinese herb combination dosage after single oral with oral administration, or morphine, morphine traditional Chinese herb combination dosage after single oral administration in healthy volunteers under fasting conditions.

Inclusion Criteria:

• Normal healthy adult subjects between 20-40 years of age
• Body weight within 80-120% of ideal body weight
• Acceptable medical history, physical examination and clinical laboratory determinations

Exclusion Criteria:

• Recent history of drug or alcohol addiction or abuse
• Donating greater than 150 ml of blood within two months prior to Period I
• Taking any prescription medication or any nonprescription medication within 14 days prior to Period I doing
• Receiving any investigational drug within 30 days prior to Period I dosing
• Taking any drug known to induce or inhibit hepatic drug metabolism within 30 days prior to the beginning of the study
• Any clinically significant diseases
• History of allergic response to nalbuphine or related drugs and traditional Chinese herbs