The primary objective of this NIS is to assess the clinical benefit subjects derive from taking seroquel XR, using the CGI-CB. The secondary objective is to assess the effectiveness,safety and tolerability of seroquel XR tablets.

Inclusion Criteria:

• Diagnosed as Schizophrenia according to DSM-IV-TR criteria
• Patients who are taking Seroquel XR no longer than 1 month
• Patients who get antipsychotics monotherapy at least 1 week before enroll in this study

Exclusion Criteria:

• First episode, drug naive schizophrenic subjects.
• Meeting the criteria for any other (than schizophrenia) DSM-IV Axis I diagnosis,concomitant organic mental disorder or mental retardation that in the opinion of the Principal Investigator may interfere with study conduct or interpretation.
• Known lack of response to clozapine or treatment with clozapine within 4 weeks prior to enrollment.

Adult diagnosed as Schizophrenia according to DSM-IV-TR criteria, the groups will be selected selected from general hospital or mental hospital.