1. To assess the safety, reactogenicity, tolerability, and adverse events (AEs) of the VAX102 vaccine in a two dose regimen (Day 0 and Day 28) at the 1.0 µg dose level delivered i.m., or the 2.0 µg dose level delivered s.c. in a healthy adult population.
2. To assess the immunogenicity (anti-M2e serum antibody concentration) of the VAX102 vaccine in a two dose regimen (Day 0 and Day 28) at the 1.0 µg dose level delivered i.m., or the 2.0 µg dose level delivered s.c. as measured by an enzyme-linked immunosorbent assay (ELISA) in a healthy adult population.

Inclusion Criteria:

• Adult men or women aged 18 to 49 years inclusive.
• Able and willing to provide written informed consent to participate.
• Healthy, as determined by medical history, physical examination, and vital signs.
• Willing to receive the unlicensed (VAX102) vaccine given as an i.m. or s.c. injection.
• Willing to provide multiple blood specimens collected by venipuncture.
• Females should avoid becoming pregnant during the course of the study
• Women of childbearing potential must have a negative urine pregnancy test within 24 hours preceding receipt of the first and preceding receipt of the second (booster) vaccination.
• Must exhibit comprehension of the study requirements; expressed availability for the required study period and expect to reside in the study area during the entire study period, and ability to attend scheduled visits.

Exclusion Criteria:

• Persons under 18 years old or 50 years or older.
• Persons with chronic illnesses such as cancer, diabetes, liver or kidney disease.
• Person currently pregnant, nursing mothers or planning a pregnancy within one month of vaccination.
• Persons who have had a prior serious reaction to influenza vaccine.
• Persons with a history of anaphylactic-type reaction to injected vaccines.
• Persons with a history of drug or chemical abuse in the year preceding the study.
• Persons who received an influenza vaccine for the current influenza season or those who plan to receive an influenza vaccine while participating in the study.
• Persons who received any other vaccine within one week prior to enrollment (may delay enrollment).
• Persons who have had a respiratory illness or illness with fever within three days of study enrollment (may delay enrollment).
• Persons currently participating in another research study involving any study medications (medicines or vaccines).