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| ID | Type | Description | Link |
|---|---|---|---|
| 2008-72VP-15445-01A | |||
| ALFFGBG-10984 |
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Hypothesis The overall hypothesis is that non-obese (BMI <30) women with PCOS have high luteinising hormone (LH) and cortisol pulse frequency and amplitude and that repeated low-frequency EA restore these alterations and induce ovulation.
Aim 1. Elucidate if low-frequency EA induce ovulation and restore LH frequency and amplitude as well as sex steroid secretion as compared to a control group receiving same amount of attention.
Aim 2. Elucidate if low-frequency EA restore cortisol frequency and amplitude compared to a control group receiving same amount of attention.
Aim 3. Elucidate if low-frequency EA restore psychological distress and quality of life as compared to a control group receiving same amount of attention.in women with PCOS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low-frequency electro-acupuncture | Experimental |
| |
| Meeting a therapist - attention | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low-frequency electro-acupuncture (EA) | Device | 2 Hz EA during 30 minutes, twice a week, 14 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Frequent blood sampling every 10th minute during an overnight stay in order to measure changes in LH and cortisol pulsatility before and after treatment. A third assessment will be made in those participants who ovulate during the 14 week study. | 16 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Ovulation, health related quality of life | 16 weeks |
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Inclusion Criteria:
Exclusion Criteria:
Medical Exclusion Criteria
Psychiatric and Behavioral Exclusion Criteria
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Neuroscience and Physiology, Sahlgrenska Academy, Göteborg University | Gothenburg | 40530 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23482444 | Derived | Johansson J, Redman L, Veldhuis PP, Sazonova A, Labrie F, Holm G, Johannsson G, Stener-Victorin E. Acupuncture for ovulation induction in polycystic ovary syndrome: a randomized controlled trial. Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E934-43. doi: 10.1152/ajpendo.00039.2013. Epub 2013 Mar 12. |
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| ID | Term |
|---|---|
| D011085 | Polycystic Ovary Syndrome |
| ID | Term |
|---|---|
| D010048 | Ovarian Cysts |
| D003560 | Cysts |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 |
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| Meeting a therapist - attention control | Other | Meeting a therapist, twice a week during 30 minutes in order to control for the increased amount of attention. |
|
| Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |