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| Name | Class |
|---|---|
| Canadian Institutes of Health Research (CIHR) | OTHER_GOV |
| GlaxoSmithKline | INDUSTRY |
| AstraZeneca | INDUSTRY |
| Pfizer |
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Abstract Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in Canada. COPD is not just a disease of men, nor is it solely a disease in old age. Women have been underrepresented and early disease has not been studied. Underdiagnosis of COPD remains a significant problem, and it may indicate an unmet healthcare need. This can potentially results not only in a patient been misinformed, but can lead to incorrect management.
Epidemiological research is needed to develop a framework to combat this major health problem, by better characterization of the population of men and women at risk and patients with early disease, by better understanding which factors modifiable through health interventions are related to health perception (health-related quality of life) and disease evolution.
This will be possible through a nationwide study, the Canadian Cohort Obstructive Lung disease (CanCOLD), a prospective longitudinal study. The CanCOLD study is built on the current ongoing prevalence nationwide study, the Canadian Obstructive Lung disease "COLD" study.
The CanCOLD will be the first study to assess prevalence of disease across Canada and its consequence in men and women, and to evaluate a conceptual model of disease severity based on patient's health perception (health-related quality of life). Ultimately, this project will extend to a longitudinal follow up (3 years or beyond) and will allow to have a better understanding of the lifestyle risk factors, not only smoking but also diet, physical activity, and co morbid conditions. This will be a great asset to shift from management of a single risk factor (tobacco control) to total COPD risk management. The results of the study will greatly help to assist decision makers in developing policies to improve the diagnosis, the management of COPD and to optimize health care services use.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | COPD moderate-severe(GOLD2-4)(post-BD FEV1/FVC<0.70 and FEV1<80% of pred.) | ||
| Group 2 | COPD mild (GOLD1)(post-BD FEV1/FVC<0.70 AND FEV1>=80% of pred.) | ||
| Group 3 | COPD at risk (ever smoker with post-BD FEV1/FVC>=0.70) | ||
| Group 4 | "Healthy control" never smokers without respiratory disease (post-BD FEV1/FVC>=0.70. |
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| Measure | Description | Time Frame |
|---|---|---|
| What risk factors other than smoking determine the development and progression of COPD. | One visit a year every 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| What are the combinations of the disease and patient attributes that differentiate individuals (men/women) with COPD as they relate to relevant outcomes (symptoms, exacerbations, disease progression or death) | One visit a year 18 months | |
| Is early detection of COPD with spirometry meaningful according to sex and ageing. |
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Inclusion Criteria:
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Subjects' selection and participation in CanCOLD- longitudinal cohort: Subjects will be recruited from the study site participants (total from cross-sectional ≈5,000 subjects, men and women).
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| Name | Affiliation | Role |
|---|---|---|
| Jean Bourbeau, M.D., M.Sc. | McGill University Health Centre/Research Institute of the McGill University Health Centre | Principal Investigator |
| Wan Tan, M.D. | CAAA University of British Columbia | Principal Investigator |
| François Maltais, M.D. | CFBA Université Laval | Principal Investigator |
| Shawn Aaron, M.D., M.Sc. | OHGC Ottawa Hospital General Campus | Principal Investigator |
| Denis O'Donnell, M.D. | CEDA Queen's University (Kinsgston) | Principal Investigator |
| Darcy D Marciniuk, M.D. | CCAA University of Saskatchewan | Principal Investigator |
| Robert Cowie, M.D. | CBBA University of Calgary | Principal Investigator |
| Kenneth R. Chapman, M.D., M.Sc. | CEAA University of Toronto | Principal Investigator |
| Paul Hernandez, M.D. | CHAA Dalhousie University (Nova Scotia) |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Health Sciences Centre | Calgary | Alberta | T2N 4N1 | Canada | ||
| St-Paul's Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41784492 | Derived | Genkin D, Verdawala M, Collins SE, Tan WC, Li PZ, Bourbeau J, Stickland MK, Jensen D, Kirby M. Deep Learning Segmentation of Pectoralis Muscle Volume at CT and Comparison with Pectoralis Muscle Area in COPD. Radiol Cardiothorac Imaging. 2026 Apr;8(2):e250060. doi: 10.1148/ryct.250060. | |
| 40205553 | Derived | Cordero AIH, Li X, Yang CX, Ambalavanan A, MacIsaac JL, Kobor MS, Doiron D, Tan W, Bourbeau J, Sin DD, Duan Q, Leung JM; CanCOLD Collaborative Research Group. Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation. BMC Pulm Med. 2025 Apr 9;25(1):168. doi: 10.1186/s12890-025-03634-9. |
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publications; data sharing through substudies submission
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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| INDUSTRY |
| Boehringer Ingelheim | INDUSTRY |
| Novartis | INDUSTRY |
| Takeda | INDUSTRY |
| Merck Sharp & Dohme LLC | INDUSTRY |
| Almirall, SAS | INDUSTRY |
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Blood sampling
| One visit a year 18 months |
| Mark J. FitzGerald, M.D. | CAAA University of British Columbia | Principal Investigator |
| Donald Sin, M.D. | CAAA University of British Columbia | Principal Investigator |
| Andrea Benedetti, Ph.D. | INUD McGill University Healty Center | Principal Investigator |
| Yves Lacasse, M.D., M.Sc. | CPVR Institut universitaire de cardiologie et de pneumologie de Québec | Principal Investigator |
| Pierre Ernst, M.D. | McGill University | Principal Investigator |
| Harvey Coxson, M.D. | University of British Columbia | Principal Investigator |
| Roger Goldstein, M.D. | CEAA University of Toronto | Principal Investigator |
| Carlo Marra, Ph.D. | CAAA University of British Columbia | Principal Investigator |
| Vancouver |
| British Columbia |
| V6Z 1Y6 |
| Canada |
| Halifax Infirmary | Halifax | Nova Scotia | B3H 3A7 | Canada |
| Kingston General Hospital | Kingston | Ontario | K7L 2V6 | Canada |
| Ottawa Hospital General | Ottawa | Ontario | K1H 8L6 | Canada |
| University of Toronto | Toronto | Ontario | M5T 2S8 | Canada |
| Montreal Chest Institute | Montreal | Quebec | H2X 2P4 | Canada |
| Royal University Hospital | Saskatoon | Saskatchewan | S7N 0W8 | Canada |
| Institut universitaire de cardiologie et de pneumologie de Québec | Québec | G1V 4G5 | Canada |
| 39490971 | Derived | Ekstrom M, Lewthwaite H, Li PZ, Bourbeau J, Tan WC, Jensen D; CanCOLD Collaborative Research Group. Identifying Abnormal Exertional Breathlessness in COPD: Comparing Modified Medical Research Council and COPD Assessment Test With Cardiopulmonary Exercise Testing. Chest. 2025 Mar;167(3):697-711. doi: 10.1016/j.chest.2024.10.027. Epub 2024 Oct 28. |
| 39012250 | Derived | Virdee S, Tan WC, Hogg JC, Bourbeau J, Hague CJ, Kirby M; CanCOLD Collaborative Research Group. CT Chest Imaging Using Normalized Join-Count: Predicting Emphysema Progression in the CanCOLD Study. Radiology. 2024 Jul;312(1):e233265. doi: 10.1148/radiol.233265. |
| 38170674 | Derived | Phillips DB, James MD, Vincent SG, Elbehairy AF, Neder JA, Kirby M, Ora J, Day AG, Tan WC, Bourbeau J, O'Donnell DE; CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network. Physiological Characterization of Preserved Ratio Impaired Spirometry in the CanCOLD Study: Implications for Exertional Dyspnea and Exercise Intolerance. Am J Respir Crit Care Med. 2024 Jun 1;209(11):1314-1327. doi: 10.1164/rccm.202307-1184OC. |
| 37173074 | Derived | Abozid H, Kirby M, Nasir N, Hartl S, Breyer-Kohansal R, Breyer MK, Burghuber OC, Bourbeau J, Wouters EFM, Tan W; CanCOLD Collaborative research Group and the Canadian Respiratory Research Network. CT airway remodelling and chronic cough. BMJ Open Respir Res. 2023 May;10(1):e001462. doi: 10.1136/bmjresp-2022-001462. |
| 37147124 | Derived | Ross BA, Doiron D, Benedetti A, Aaron SD, Chapman K, Hernandez P, Maltais F, Marciniuk D, O'Donnell DE, Sin DD, Walker BL, Tan W, Bourbeau J; CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network. Short-term air pollution exposure and exacerbation events in mild to moderate COPD: a case-crossover study within the CanCOLD cohort. Thorax. 2023 Oct;78(10):974-982. doi: 10.1136/thorax-2022-219619. Epub 2023 May 5. |
| 36871842 | Derived | Krishnan S, Tan WC, Farias R, Aaron SD, Benedetti A, Chapman KR, Hernandez P, Maltais F, Marciniuk DD, O'Donnell DE, Sin DD, Walker B, Bourbeau J; Canadian Cohort Obstructive Lung Disease Collaborative Research Group and the Canadian Respiratory Research Network. Impaired Spirometry and COPD Increase the Risk of Cardiovascular Disease: A Canadian Cohort Study. Chest. 2023 Sep;164(3):637-649. doi: 10.1016/j.chest.2023.02.045. Epub 2023 Mar 4. |
| 35690537 | Derived | Moslemi A, Makimoto K, Tan WC, Bourbeau J, Hogg JC, Coxson HO, Kirby M; Canadian Cohort of Obstructive Lung Disease. Quantitative CT Lung Imaging and Machine Learning Improves Prediction of Emergency Room Visits and Hospitalizations in COPD. Acad Radiol. 2023 Apr;30(4):707-716. doi: 10.1016/j.acra.2022.05.009. Epub 2022 Jun 8. |
| 35333135 | Derived | Phillips DB, Elbehairy AF, James MD, Vincent SG, Milne KM, de-Torres JP, Neder JA, Kirby M, Jensen D, Stickland MK, Guenette JA, Smith BM, Aaron SD, Tan WC, Bourbeau J, O'Donnell DE; CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network. Impaired Ventilatory Efficiency, Dyspnea, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease: Results from the CanCOLD Study. Am J Respir Crit Care Med. 2022 Jun 15;205(12):1391-1402. doi: 10.1164/rccm.202109-2171OC. |
| 33303555 | Derived | Tan WC, Bourbeau J, Nadeau G, Wang W, Barnes N, Landis SH, Kirby M, Hogg JC, Sin DD; CanCOLD Collaborative Research Group; authors would also like to thank the men and women who participated in the study and individuals in the CanCOLD Collaborative Research Group not listed as authors:. High eosinophil counts predict decline in FEV1: results from the CanCOLD study. Eur Respir J. 2021 May 27;57(5):2000838. doi: 10.1183/13993003.00838-2020. Print 2021 May. |
| 33217419 | Derived | Lewthwaite H, Elsewify O, Niro F, Bourbeau J, Guenette JA, Maltais F, Marciniuk DD, O'Donnell DE, Smith BM, Stickland MK, Tan WC, Jensen D; CanCOLD Collaborative Research Group; Canadian Respiratory Research Network. Normative Cardiopulmonary Exercise Test Responses at the Ventilatory Threshold in Canadian Adults 40 to 80 Years of Age. Chest. 2021 May;159(5):1922-1933. doi: 10.1016/j.chest.2020.11.009. Epub 2020 Nov 18. |
| 32064708 | Derived | Barrecheguren M, Pinto L, Mostafavi-Pour-Manshadi SM, Tan WC, Li PZ, Aaron SD, Benedetti A, Chapman KR, Walker B, Fitzgerald JM, Hernandez P, Maltais F, Marciniuk DD, O'Donnell DE, Sin DD, Bourbeau J; CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network. Identification and definition of asthma-COPD overlap: The CanCOLD study. Respirology. 2020 Aug;25(8):836-849. doi: 10.1111/resp.13780. Epub 2020 Feb 16. |
| 27364603 | Derived | Gupta N, Pinto L, Benedetti A, Li PZ, Tan WC, Aaron SD, Chapman KR, FitzGerald JM, Hernandez P, Marciniuk DD, Maltais F, O'Donnell DE, Sin D, Walker BL, Bourbeau J; Canadian Respiratory Research Network and the CanCOLD Collaborative Research Group. The COPD Assessment Test: Can It Discriminate Across COPD Subpopulations? Chest. 2016 Nov;150(5):1069-1079. doi: 10.1016/j.chest.2016.06.016. Epub 2016 Jun 27. |
| 26048404 | Derived | Tan WC, Sin DD, Bourbeau J, Hernandez P, Chapman KR, Cowie R, FitzGerald JM, Marciniuk DD, Maltais F, Buist AS, Road J, Hogg JC, Kirby M, Coxson H, Hague C, Leipsic J, O'Donnell DE, Aaron SD; CanCOLD Collaborative Research Group. Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study. Thorax. 2015 Sep;70(9):822-9. doi: 10.1136/thoraxjnl-2015-206938. Epub 2015 Jun 5. |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |