AZD1981 Bioavailability Study of Intravenous (IV) and Oral Formulations

An Open, Single-dose, Phase I, 4-period Partly Crossover Study in Healthy Men or Women to Assess Relative Bioavailability of Oral Administration of AZD1981 Via Tablets Compared With Suspension and Basic Systemic Pharmacokinetic Parameters After Intravenous Administration

The primary objective is to investigate the pharmacokinetics of AZD1981 given in different formulations and to measure renal clearance

Inclusion Criteria:

• Provision of informed consent prior to any study specific procedures
• Men or post-menopausal or surgically sterile women, aged 18 to 55 years
• Have a body mass index between 19 and 30 kg/m2 and weigh at least 50 kg and no more than 100 kg
• Be a non-smoker or ex-smoker who has stopped smoking for >6 months prior to Visit 1 (pre-entry)

Exclusion Criteria:

• Any clinically significant disease or disorder which, in the opinion of the investigator, may either put the subject at risk because of participation in the study, or influence the result of the study, or the subject´s ability to participate
• Any clinically relevant abnormal findings in phys.examination, clinical chemistry, haematology, urinalysis, vital signs, or ECG at baseline which, in the opinion of the investigator, may put the subject at risk because of his participation in the study