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| ID | Type | Description | Link |
|---|---|---|---|
| 2009_600 |
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This study will evaluate ATP-induced Pain (AIP) and ATP-induced dermal vasodilation (AIDV) as target engagement tools for future development of analgesics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | ATP |
|
| 2 | Placebo Comparator | Saline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Comparator: Iontophoresis and Laser Doppler with ATP | Procedure | Iontophoresis treatments with 10 mM ATP (adenosine triphosphate) solution and a current of 0.8 or 1.2 mA. Iontophoresis treatments will last 4 minutes. Laser doppler will be used during the iontophoresis treatments to measure dermal blood flow. |
| Measure | Description | Time Frame |
|---|---|---|
| Degree of pain induced by ATP vs. saline iontophoresis | 4 minutes | |
| Increase in blood flow induced by ATP iontophoresis | 8 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Test-retest reproducibility and intra-subject variability of AIP and AIDV | 8 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Medical Monitor | Merck Sharp & Dohme LLC | Study Director |
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| Comparator: Iontophoresis and Laser Doppler with Saline | Procedure | Iontophoresis treatments with 20 mM saline solution and a current of 0.8 or 1.2 mA. Iontophoresis treatments will last 4 minutes. Laser doppler will be used during the iontophoresis treatments to measure dermal blood flow. |
|
| ID | Term |
|---|---|
| D000255 | Adenosine Triphosphate |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D000227 | Adenine Nucleotides |
| D011685 | Purine Nucleotides |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D009711 | Nucleotides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D012265 | Ribonucleotides |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |
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