Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease

Randomized Placebo-controlled Crossover Trial of Endothelial Function Improvement in Subjects With History of Premature Coronary Artery Disease

The aim of this prospective study is to investigate the prevalence of endothelial dysfunction in subjects with family history of premature coronary heart disease. At the same time, the effect of atorvastatin in treating subclinical endothelial dysfunction in those patients will be evaluated.

Inclusion Criteria:

• within 1 year
• the siblings of premature coronary heart disease(male<55years old, female<65years old: Framingham Heart Study)patients admitted relevant hospital

Exclusion Criteria:

• Documented coronary heart disease
• Any woman of childbearing potential who is pregnant, seeking to become pregnant or suspects that she may be pregnant.