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The aim of the protocol is to better understand the impairments in visual processing, as such impairments may induce social interaction difficulties in subjects with autism spectrum disorders (adults and children) and schizophrenia, like face exploration.The same protocol will be used for the three populations, each population being compared with matched controls. The explorations are designed to test two different hypotheses regarding the mechanisms of the visual perception difficulties of the two populations. Even though difficulties to extract the global form of objects have been described in both subjects with autism and schizophrenia, we will test two different hypotheses for the two populations. We will test the hypothesis that subjects with autism display an advantage for the processing of local information arising at an early level of processing, whereas disorders observed in patients with schizophrenia originate from attention disorders. The protocol includes three consecutive studies, each one being applied in each of the three populations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A1 | Patients with schizophrenia |
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| A2 | Control subjects matched individually with patients with schizophrenia |
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| B1 | Adult subjects with autism |
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| B2 | Control subjects matched individually with adult subjects with autism |
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| C1 | Children with autism |
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| C2 | Control subjects matched individually with children with autism |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neuropsychological evaluation | Other | Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear |
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Exclusion Criteria:
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Psychiatry clinic in Strasbourg and Brumath. Pedopsychiatry Clinic in Strasbourg. Residents of Strasbourg and Brumath
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| GIERSCH Anne, MD | Contact | giersch@unistra.fr |
| Name | Affiliation | Role |
|---|---|---|
| Anne GIERSCH | Institut National de la Santé Et de la Recherche Médicale, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pôle départemental du Centre de Ressources Autisme pour adultes (67) - Etablissement public de santé Alsace-Nord (site de Brumath) | Recruiting | Brumath | 67170 | France |
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
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| Centre de Ressources Autisme Pôle adultes (68) - Espace Autisme 68 | Recruiting | Colmar | 68000 | France |
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| Clinique Lautréamont | Recruiting | Loos | 59120 | France |
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| Pôle régional du Centre de Ressources Autisme pour enfants et adolescents - Unité d'évaluation des troubles du développement Hôpital de l'Elsau - Pôle de Psychiatrie - Unité d'évaluation des troubles du développement Hôpital de l'Elsau - HUS | Recruiting | Strasbourg | 67000 | France |
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| INSERM U666 ; Pôle de Psychiatrie - Service de Psychiatrie Adulte- HUS | Recruiting | Strasbourg | 67091 | France |
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