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This study assess the safety/tolerability, PK/PD of LCZ696 in patients with stable heart failure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stable heart failure patients | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LCZ696 | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Safety (including blood pressure, renal function and serum electrolytes) and tolerability of LCZ696 | 14 days |
| Measure | Description | Time Frame |
|---|---|---|
| Pharmacokinetics of LCZ696 and its metabolites | 14 days | |
| Pharmacodynamics of LCZ696 | 14 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Novartis Pharmaceuticals | Novartis Pharmaceuticals | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| GOUVPO Russian Peoples´ Friendship University, Center of Applied | Moscow | 117198 | Russia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26990595 | Result | Kobalava Z, Kotovskaya Y, Averkov O, Pavlikova E, Moiseev V, Albrecht D, Chandra P, Ayalasomayajula S, Prescott MF, Pal P, Langenickel TH, Jordaan P, Rajman I. Pharmacodynamic and Pharmacokinetic Profiles of Sacubitril/Valsartan (LCZ696) in Patients with Heart Failure and Reduced Ejection Fraction. Cardiovasc Ther. 2016 Aug;34(4):191-8. doi: 10.1111/1755-5922.12183. |
| Label | URL |
|---|---|
| Results for CLCZ696A2117 from the Novartis Clinical Trials Website | View source |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| C549068 | sacubitril and valsartan sodium hydrate drug combination |
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