A Bioequivalence Study of Serum Free Avonex and Serum Containing Avonex in Healthy Volunteers

A Randomized, Single-Blind, Crossover Study in Healthy Volunteers to Demonstrate the Bioequivalence of AVONEX® (Interferon Beta-1a) Solutions for Injection Produced by a Serum-Containing Manufacturing Process and by a Serum-Free Manufacturing Process

Demonstrate the bioequivalence of a serum-free solution to a serum containing solution of Avonex.

Inclusion Criteria:

• Healthy Volunteers

Exclusion Criteria:

• History of severe allergic or anaphylactic reactions
• History of hypersensitivity to acetaminophen (paracetamol), ibuprofen, or codeine.
• Known allergy to dry natural rubber
• History of seizure disorder or unexplained blackouts
• History of any clinically significant (as determined by the Investigator) cardiac, endocrinologic, hematologic, hepatic, immunologic, metabolic, urologic, pulmonary, neurologic, dermatologic, psychiatric, renal, and/or other major disease

Other inclusion and exclusion criteria apply as per protocol