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The broad aim is to determine efficacy of a weight loss diet higher in protein and lower in carbohydrate combined with low intensity exercise to favorably impact body composition, bone health, physical function, metabolic disease and quality of life compared to a conventional higher carbohydrate diet in overweight women over age 60.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Higher protein | Active Comparator |
| |
| Higher carbohydrate | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whey protein isolate | Dietary Supplement | Loss of 10% baseline weight over 6 months, with whey protein isolate supplemented at 50g/day (two 25 g doses taken at breakfast and afternoon snack mixed with food or beverage) |
| Measure | Description | Time Frame |
|---|---|---|
| Bone and body composition: Weight, percent fat, muscle and fat distribution in the thigh and abdomen and bone density and structural quality assessed by DXA and structural MRI | Baseline and post 6 months weight loss |
| Measure | Description | Time Frame |
|---|---|---|
| Physical function: balance, gait, strength and activities of daily living | Baseline and post 6 months weight loss | |
| Quality of life | Baseline and post 6 months weight loss | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ellen M Evans, PhD | University of Illinois at Urbana-Champaign | Principal Investigator |
| Donald K Layman, PhD | University of Illinois at Urbana-Champaign | Principal Investigator |
| Edward McAuley, PhD | University of Illinois at Urbana-Champaign | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Illinois at Urbana-Champaign | Urbana | Illinois | 61801 | United States |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D002241 | Carbohydrates |
| D013213 | Starch |
| ID | Term |
|---|---|
| D005936 | Glucans |
| D001704 | Biopolymers |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
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| Maltodextrin powder supplement | Dietary Supplement | Loss of 10% baseline weight over 6 months, with whey protein isolate supplemented at 50 g / day (two 25 g doses at breakfast and afternoon snack mixed with food or beverage) |
|
|
| Metabolic syndrome: insulin resistance, blood pressure, blood lipids, waist circumference |
| Baseline and post 6 months weight loss |
| Acid-base balance | Baseline and post 1 and 6 months weight loss |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004040 |
| Dietary Carbohydrates |
| D011134 | Polysaccharides |