Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study is a comparison of two most commonly used modes of weaning and the outcomes in the two groups.
Patients ventilated for more than 24 hours are randomized into two groups - one group of patients undergo gradual reduction of pressure support and in the other, T tube trials are used for weaning. The outcomes are compared in the two groups.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pressure support ventilation | Active Comparator | Patients in this arm are weaned by gradual reduction of pressure support |
|
| Spontaneous breathing trials | Active Comparator | Patients in this arm are weaned by T piece trials |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pressure support ventilation | Procedure | These patients are weaned by gradual reduction of pressure support and extubated when they tolerate a pressure support of 7 cm of water for one hour. |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of weaning failure | 48 hours from extubation |
| Measure | Description | Time Frame |
|---|---|---|
| Occurence of ventilator associated pneumonia | Until the date of discharge from hospital | |
| Reintubation rates | 48 hours | |
| Mortality rates |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dr. Ritesh Agarwal, MD, DM | Contact | +919914209825 | riteshpgi@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Dr. Ashutosh Aggarwal, MD, DM | Department of Pulmonary Medicine and Critical Care, Postgraduate Institute of Medical Education and Research | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Postgraduate Institute of Medical Education and Research | Recruiting | Chandigarh | Chandigarh | 160012 | India |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 7823995 | Result | Esteban A, Frutos F, Tobin MJ, Alia I, Solsona JF, Valverdu I, Fernandez R, de la Cal MA, Benito S, Tomas R, et al. A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group. N Engl J Med. 1995 Feb 9;332(6):345-50. doi: 10.1056/NEJM199502093320601. | |
| 7921460 | Result |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D053120 | Respiratory Aspiration |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Spontaneous breathing trials | Procedure | These patients are weaned by giving a T piece trial with 8 cm of water pressure support and extubated when they tolerate it for one hour. |
|
|
| Until the time of discharge from hospital |
| Duration from start of weaning to extubation | In hospital stay |
| Role of various factors that may influence the weaning outcome and hence predict the probability of successful weaning in a patient | during ICU stay |
| The influence of weaning outcome on mortality and the other complications of mechanical ventilation | during hospital stay |
| Brochard L, Rauss A, Benito S, Conti G, Mancebo J, Rekik N, Gasparetto A, Lemaire F. Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med. 1994 Oct;150(4):896-903. doi: 10.1164/ajrccm.150.4.7921460. |
| 9279224 | Result | Esteban A, Alia I, Gordo F, Fernandez R, Solsona JF, Vallverdu I, Macias S, Allegue JM, Blanco J, Carriedo D, Leon M, de la Cal MA, Taboada F, Gonzalez de Velasco J, Palazon E, Carrizosa F, Tomas R, Suarez J, Goldwasser RS. Extubation outcome after spontaneous breathing trials with T-tube or pressure support ventilation. The Spanish Lung Failure Collaborative Group. Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):459-65. doi: 10.1164/ajrccm.156.2.9610109. |