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Hepatocellular carcinoma is an aggressive disease with limited therapeutic options. Therefore, new approaches to treat this type of cancer are needed with immunotherapy potentially being one of these. As a first step in the development of novel therapies, expression analysis of specific markers, including tumor antigens will be carried out, and the correlation of expression with disease variables and clinical outcome will be assessed. This will be done retrospectively using archived hepatocellular carcinoma tissue samples.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Retrospective analysis of already archived samples | Other | Analysis using RNA extracted from tissue samples already archived; Analysis by Fluorescent in situ hybridization (FISH) using tissue samples already archived. |
| Measure | Description | Time Frame |
|---|---|---|
| The proportion of hepatocellular carcinoma patients whose tumor tissue expresses specific tumor antigens. | At the time of analysis | |
| The prognostic character of the expression of the tumor antigens | At the time of analysis | |
| Expression of c-MET in the same hepatocellular carcinoma tumor samples | At the time of analysis |
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Inclusion Criteria:
Exclusion Criteria:
N/A
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Primary care clinic
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| Name | Affiliation | Role |
|---|---|---|
| GSK Clinical Trials | GlaxoSmithKline | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| GSK Investigational Site | Taipei | 100 | Taiwan | |||
| GSK Investigational Site |
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| ID | Term |
|---|---|
| D006528 | Carcinoma, Hepatocellular |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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This retrospective study is based upon the analysis of archived samples and patient-related data already available at the investigational site
| Bangkok |
| 10700 |
| Thailand |
| GSK Investigational Site | Chiang Mai | 50200 | Thailand |
| D009369 | Neoplasms |
| D008113 | Liver Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |