The purpose of this study is to assess the safety and effectiveness of natural killer (NK) cell and natural killer T (NKT) cell-based autologous adoptive immunotherapy in subjects with metastatic, treatment-refractory breast cancer, glioma, hepatocellular carcinoma, squamous cell lung cancer, pancreatic cancer, colon cancer or prostate cancer.

Inclusion Criteria:

• Male or female not less than 18 years of age or over 80 years of age.
• Life expectancy of ≥ 24 weeks as measured by the Eastern Cooperative Oncology Group (ECOG) performance status.
• Subjects must present with one of the following disease pathologies: Breast Cancer, Glioma, Hepatocellular Cancer, Squamous Cell Lung Cancer, Pancreatic Cancer, Colon Cancer or Prostate Cancer
• The pathology must be an assessable disease (measurable by CT scan or MRI) that is refractory to standard treatments (e.g., chemotherapy, radiation, etc.)
• Negative for hepatitis B, hepatitis C, HIV, and CMV.
• Subjects must present with leukocyte counts above 3,000/μL and platelet counts above 100,000/ μL.
• Subjects must present with minimum hemoglobin levels of 10.
• If female, subject is surgically sterile (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy), post menopausal (no menses >12 months), or using a high-efficiency method of contraception such as implant, injectable, combination oral contraceptive, intrauterine device (IUD) or sexual abstinence, or has a vasectomized partner.
• If female of childbearing potential, subject is not pregnant, breast-feeding or planning a pregnancy during the study, and has a negative pregnancy test on screening visit.
• Able to comprehend and sign an informed consent document and comply with the requirements of the study.

Exclusion Criteria:

• No measurable malignant disease by CT scan or tumor markers.
• Life expectancy of ≤ 24 weeks as measured by the Eastern Cooperative Oncology Group (ECOG) performance status.
• Age of less than 18 years or over 80 years of age.
• Documented/confirmed positive testing for hepatitis B, hepatitis C, HIV, or CMV.
• Prior or current history of autoimmune disease.
• Pregnant or lactating women.
• Leukocyte count < 3,000 /μL prior to leukapheresis.
• Platelet count < 100,000/μL prior to leukapheresis.
• Hemoglobin levels below 10.
• PTT (prothrombin time) of < 12 seconds or > than 15 seconds.
• aPTT (activated partial thromboplastin time) of < 25 seconds or > than 39 seconds.
• Failure or refusal to sign informed consent for the study.
• Culture fails to meet specifications for study.
• Subject has any other medical condition that, in the opinion of the investigator, might significantly affect the ability to safely participate in the study or affect the conduct of the study.