The study is to evaluate safety, efficacy and pharmacokinetics of intravenously administered fosphenytoin in patients with neurosurgery, head trauma, epilepsy or status epilepticus who are requiring a loading dose of phenytoin.

Inclusion Criteria:

• male or female, hospitalized patients 2 years of age or older
• Adult patients or guardian for pediatric patients to provide written informed consent

Exclusion Criteria:

• patient with a history of hypersensitivity to hydantoins
• patient with hypotension, sinus bradycardia, sino-atrial block, second or third degree A-V block, or Adams-Stokes syndrome
• pregnant or nursing female patients