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| Name | Class |
|---|---|
| TrygFonden, Denmark | INDUSTRY |
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The purpose of this study is to determine whether a higher threshold for transfusion with red blood cells improves the postoperative ambulation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Allowed drop in hemoglobin to 4.5-5.5 mmol/L | Active Comparator | Transfusion with red blood cells to level between 4.5-5.5 mmol/L |
|
| Allowed drop in hemoglobin to 5.6-6.5 mmol/L | Experimental | Transfusion with red blood cells to level between 5.6-6.5 mmol/L |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Allowed drop in hemoglobin to 4.5-5.5 mmol/L | Other | Transfusion with red blood cells to hemoglobin between 4.5-5.5 mmol/L (Transfusion threshold of 4.5 mmol/L) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Timed Up and Go-test (TUG)in seconds. | Timed Up and Go-test is performed when the patient is able to undertake the test after surgery. This is judged by a physiotherapist. The test measures how long it takes the patient to rise, walk 3 meters, turn around, walk back and sit down again. | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| The postoperative day patients can walk ten meters | 30 days | |
| Length of stay at hospital | 30 days | |
| The day the patient is able to perform Timed Up and Go-test |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kamilla Nielsen, MD | Rigshospitalet, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bispebjerg Hospital | Copenhagen | Copenhagen NV | 2400 | Denmark | ||
| Copenhagen University Hospital, Rigshospitalet |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41114449 | Derived | Carson JL, Stanworth SJ, Dennis JA, Fergusson DA, Pagano MB, Roubinian NH, Turgeon AF, Valentine S, Trivella M, Doree C, Hebert PC. Transfusion thresholds and other strategies for guiding red blood cell transfusion. Cochrane Database Syst Rev. 2025 Oct 20;10(10):CD002042. doi: 10.1002/14651858.CD002042.pub6. | |
| 34932836 | Derived |
| Label | URL |
|---|---|
| Official hospital homepage | View source |
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| ID | Term |
|---|---|
| D000740 | Anemia |
| ID | Term |
|---|---|
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| Allowed drop in hemoglobin to level between 5.6-6.5 mmol/L | Other | Transfusion with red blood cells to between hemoglobin 5.6-6.5 mmol/L (Transfusion threshold of 5.5 mmol/L) |
|
| 30 days |
| Copenhagen |
| Østerbro |
| 2100 |
| Denmark |
| Carson JL, Stanworth SJ, Dennis JA, Trivella M, Roubinian N, Fergusson DA, Triulzi D, Doree C, Hebert PC. Transfusion thresholds for guiding red blood cell transfusion. Cochrane Database Syst Rev. 2021 Dec 21;12(12):CD002042. doi: 10.1002/14651858.CD002042.pub5. |
| 25337035 | Derived | Nielsen K, Johansson PI, Dahl B, Wagner M, Frausing B, Borglum J, Jensen K, Sturup J, Hvolris J, Rasmussen LS. Perioperative transfusion threshold and ambulation after hip revision surgery--a randomized trial. BMC Anesthesiol. 2014 Oct 10;14:89. doi: 10.1186/1471-2253-14-89. eCollection 2014. |