Lycopene Following Aneurysmal Subarachnoid Haemorrhage

Acute Oral Lycopene Therapy on Cerebral Autoregulation and Delayed Ischaemic Deficits Following Aneurysmal Subarachnoid Haemorrhage (LASH): A Randomized Controlled Trial

In this study the investigators wish to explore the potential neuroprotective effects of acute oral supplementation of lycopene, a natural anti-oxidant derived from tomatoes, on cerebral vasospasm and autoregulation, and examine whether any improvements translate into a reduction of biochemical markers of vascular injury and inflammation a decrease in the prevalence of secondary strokes following subarachnoid haemorrhage.

Inclusion Criteria:

• Age: > 18 years old,
• Confirmed aneurysmal subarachnoid hemorrhage (aSAH),
• Time from ictus < 96 hours

Exclusion Criteria:

• Age: < 18 years old,
• Non-aneurysmal SAH,
• Time from ictus > 96 hours,
• Severe carotid atherosclerotic disease (≥70%)
• High-dose statin therapy (>80 mg/day fluvastatin; >40 mg/day simvastatin; >40 mg/day pravastatin; >10 mg/day atorvastatin; >10 mg/day rosuvastatin 28),
• Allergy or hypersensitivity to tomatoes and tomato products and history of any other significant atopy/allergy (e.g. soy, whey, lutein, lecithin)