Effect of LY2062430, an Anti-Amyloid Beta Monoclonal Antibody, on the Progression of Alzheimer's Disease as Compared With Placebo
Effect of LY2062430, an Anti-Amyloid Beta Monoclonal Antibody, on the Progression of Alzheimer's Disease as Compared With Placebo
Alzheimer's disease (AD) is an age-related degenerative disorder of the brain, characterized by progressive decline in cognitive function and ability to perform activities of daily living, and ultimately can lead to death due to complications of the disease. AD is thought to be caused by an excess of A-Beta amyloid, a sticky protein in the brain that forms amyloid plaques. Treatments that slow the synthesis or deposition of A-Beta amyloid, or that increase clearance, might be expected to slow the progression of AD.
LY2062430 (solanezumab) is a humanized anti-A Beta peptide immunoglobulin G-1 (IgG1) monoclonal antibody being developed for the treatment of AD. The primary hypothesis being tested is that LY2062430 will slow cognitive and functional decline in AD as compared with placebo. Each patient's participation will last approximately 19 months. Patients taking approved AD medications may participate in this study and continue taking these medications during the study.
Inclusion Criteria:
Exclusion Criteria:
Phoenix, Arizona 85006, United States
Sun City, Arizona 85351, United States
Tuscon, Arizona 85718, United States
Little Rock, Arkansas 72205, United States
Carson, California 90746, United States
Irvine, California 92697, United States
Laguna Hills, California 92653, United States
Lomita, California 90717, United States
Orange, California 92868, United States
Oxnard, California 93030, United States
Santa Ana, California 92705, United States
Denver, Colorado 80239, United States
Fairfield, Connecticut 06824, United States
Hamden, Connecticut 06518, United States
New Haven, Connecticut 06510, United States
Norwalk, Connecticut 06851, United States
Newark, Delaware 19713, United States
Washington D.C., District of Columbia 20007, United States
Boca Raton, Florida 33431, United States
Fort Myers, Florida 33912, United States
Hollywood, Florida 33021, United States
Miami Springs, Florida 33166, United States
North Miami, Florida 33161, United States
Orange City, Florida 32763, United States
Orlando, Florida 32806, United States
Sunrise, Florida 33351, United States
Tampa, Florida 33613, United States
Atlanta, Georgia 30341, United States
Canton, Georgia 30114, United States
Decatur, Georgia 30033, United States
Indianapolis, Indiana 46202, United States
Lexington, Kentucky 40503, United States
Baltimore, Maryland 21285, United States
Rockville, Maryland 20852, United States
Belmont, Massachusetts 02478, United States
Grand Rapids, Michigan 49525, United States
Traverse City, Michigan 49684, United States
Albuquerque, New Mexico 87109, United States
Albany, New York 12205, United States
Latham, New York 12210, United States
New York, New York 10032, United States
Orangeburg, New York 10962, United States
The Bronx, New York 10454, United States
Raleigh, North Carolina 27607, United States
Winston-Salem, North Carolina 27103, United States
Beachwood, Ohio 44122, United States
Toledo, Ohio 43623, United States
Oklahoma City, Oklahoma 73116, United States
Eugene, Oregon 97401, United States
Philadelphia, Pennsylvania 19104, United States
East Providence, Rhode Island 02914, United States
Charleston, South Carolina 29425, United States
Greer, South Carolina 29651, United States
Sioux Falls, South Dakota 57105, United States
Salt Lake City, Utah 84108, United States
Bennington, Vermont 05201, United States
Burlington, Vermont 05401, United States
Norfolk, Virginia 23502, United States
Roanoke, Virginia 24018, United States
Buenos Aires, CBA 1419, Argentina
Córdoba, X5004AOA, Argentina
Mendoza, 5500, Argentina
Pueyrredon Cordoba, X5005ALB, Argentina
Rosario, S2000BZL, Argentina
Santa Fe, S3000FWO, Argentina
Curitiba, 81210-310, Brazil
Itapira, 13970-905, Brazil
Porto Alegre, 90110-270, Brazil
Rio de Janeiro, 20941-150, Brazil
São Paulo, 04024-002, Brazil
Medicine Hat, Alberta T1B4E7, Canada
Kelowna, British Columbia V1Y3G8, Canada
Penticton, British Columbia V2A5C8, Canada
Ottawa, Ontario K1N 5C8, Canada
Toronto, Ontario M6M 3Z5, Canada
Greenfield Park, Quebec J4V 2J2, Canada
Sherbrooke, Quebec J1H1Z1, Canada
Aichi, 474-8511, Japan
Fukuoka, 812-0033, Japan
Hiroshima, 720-0825, Japan
Kanagawa, 243-8550, Japan
Kyoto, 607-8062, Japan
Osaka, 567, Japan
Shizuoka, 420-8688, Japan