The purpose of this study is to detect recurrent bladder cancer using a combination of protein and DNA biomarkers in urine

Inclusion Criteria:

• Intact bladder
• Scheduled for cystoscopy for transitional cell bladder cancer recurrence screening
• Urine donated prior to cystoscopy, Bladder biopsy, chemotherapy, intravesical therapy, radiation or TUR
• Must be willing to sign IRB approved informed consent

Exclusion Criteria:

• History or current diagnosis of any cancer except transitional cell bladder cancer or basal cell cancer
• Known diagnosis of any autoimmune disease or HIV, HCV or HBV
• History or current TB or any other active infection
• Subject has gross hematuria
• Receiving chemotherapy, intravesical therapy or radiation within 30 days of enrollment
• Any surgery except urologic within past 30 days

The study population will be from urology and oncology practices