This study is being done to create a registry to help us learn more about urinary and other cancers. This will let us look at large groups of people who do and do not have this kind of cancer.

The investigators will look at risk factors to learn more about how these impact cancer. The investigators will also look at genetic markers. These are genes that are found in a known place. They are often associated with a particular trait. If the gene changes in some way, it may predict cancer or response to treatment. The investigators will look for markers in your saliva.

This registry will help us develop better methods of:

Preventing these cancers. Diagnosing these cancers. Treating these cancers.

Inclusion Criteria:

Urothelial Cancer Cases

• Must be ≥ 18 years of age AND
• Must have a diagnosis of urothelial cancer AND
• Must be an English-speaker

Non-Cancer Control Group

• Must be ≥ 18 years of age AND
• Must not have cancer or a personal history of cancer, with the exception of skin cancer. AND
• Must not be a blood relative of cases AND
• Must not be a blood relative of another control AND
• Must be an English-speaker

Family Member Control Group:

In select kindreds with a high prevalence of bladder cancer and/or very early onset bladder cancer, first- and second-degree family members of probands may be contacted by the MSKCC study team and invited to complete the questionnaire and submit a saliva sample.

• Must be ≥ 18 years of age AND
• Must be a blood relative of a case participant AND
• Must be an English-speaker

Exclusion Criteria:

• Have any condition, which in the opinion of the primary MSKCC clinician or investigators precludes their ability to provide informed consent.

A member of the patient's treatment team, the protocol investigator, or a member of the research team at Memorial Sloan-Kettering Cancer Center (MSKCC) will identify potential research subjects. At MSKCC the following outpatient clinics will be used to recruit UC cases: Urology and Genitourinary Oncology. Patients and families may also be directly referred to the study team by any MSKCC physician, external physician, or by the family itself.