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The study is a randomised placebo controlled double-blinded clinical trial where a group of healthy pre- and postmenopausal women is randomised to the intake of fish oil capsules or placebo oil capsules for 12 weeks. Anthropometric measurements(weight, height,blood pressure) blood samples and adipose tissue biopsies will be taken in order to illustrate the effect of marine n-3 PUFAs (fish oil) on the concentration of circulating female hormones and to investigate what impact menopause might have on the ability to incorporate marine n-3 PUFAs into tissues.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Premenopausal women-fishoil | Active Comparator |
| |
| Premenopausal-placebo | Placebo Comparator |
| |
| Postmenopausal women-fishoil | Active Comparator |
| |
| Postmenopausal-placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| marine n-3 polyunsaturated fatty acids | Dietary Supplement | Four capsules daily containing 2.2 g marine n-3 polyunsaturated fatty acids in total |
|
| Measure | Description | Time Frame |
|---|---|---|
| Content of marine n-PUFAs as percent of total content of fatty acids in adipose tissue and in platelets before and after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of oestrogen concentrations in blood before and after intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for cardiovascular research, Aalborg Hospital | Aalborg | 9000 | Denmark |
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| ID | Term |
|---|---|
| D005395 | Fish Oils |
| ID | Term |
|---|---|
| D009821 | Oils |
| D008055 | Lipids |
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|
| thistle oil | Dietary Supplement | four capsules a day |
|
| marine n-3 polyunsaturated fatty acids | Dietary Supplement | Four capsules daily, 2.2 g marine n-3 PUFAs in total |
|
|
| Thistle oil | Dietary Supplement | Four capsules daily |
|