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| ID | Type | Description | Link |
|---|---|---|---|
| SWOG-9023 | Other Identifier | SWOG | |
| U10CA032102 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
RATIONALE: DNA analysis of tumor tissue may help doctors predict how well patients will respond to treatment.
PURPOSE: This laboratory study is analyzing the DNA in tumor tissue from patients with metastatic kidney cancer.
OBJECTIVES:
OUTLINE: This is a partially prospective, partially retrospective, multicenter, companion study.
Paraffin-embedded tumor tissue specimens from patients enrolled in SWOG-8949 are evaluated by cytogenetic analysis (e.g., presence of trisomy and loss of Y chromosome) and flow cytometric analysis (e.g., presence of nondiploid cells and presence of abnormal proliferation index).
PROJECTED ACCRUAL: A total of 80 patients will be accrued for this study.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DNA ploidy analysis | Genetic | |||
| DNA stability analysis | Genetic | |||
| chromosomal translocation analysis | Genetic | |||
| cytogenetic analysis | Genetic | |||
| flow cytometry | Other | |||
| laboratory biomarker analysis | Other |
| Measure | Description | Time Frame |
|---|---|---|
| Number of successes per number of evaluable samples | Success is defined as obtaining at least 10 analyzable metaphases. | up to 4 years after registration |
| Number of abnormalities per number of successes | Abnormality is defined as at lease one clonal chromosomal abnormality. | up to 4 years after registration |
| Correlation of tumor response to treatment with the type and number of abnormalities | Abnormality is defined as at lease one clonal chromosomal abnormality. | up to 4 years after registration |
| Correlation of time from diagnosis to development of metastatic disease with the type and number of abnormalities | Abnormality is defined as at lease one clonal chromosomal abnormality. | up to 4 years after registration |
| Correlation of time from first diagnosis of metastatic disease until death with the type and number of abnormalities | Abnormality is defined as at lease one clonal chromosomal abnormality. | up to 4 years after registration |
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DISEASE CHARACTERISTICS:
Diagnosis of renal cell carcinoma
Eligible for and registered on the nephrectomy arm* (arm I) of SWOG-8949 NOTE: *Patients must be registered on this study before undergoing nephrectomy on SWOG-8949
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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| Name | Affiliation | Role |
|---|---|---|
| Robert P. Whitehead, MD | University of Texas | Study Chair |
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| ID | Term |
|---|---|
| D007680 | Kidney Neoplasms |
| D002292 | Carcinoma, Renal Cell |
| ID | Term |
|---|---|
| D014571 | Urologic Neoplasms |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D020732 | Cytogenetic Analysis |
| D005434 | Flow Cytometry |
| ID | Term |
|---|---|
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Tumor diagnostic tissue
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052801 | Male Urogenital Diseases |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D008919 | Investigative Techniques |
| D005821 | Genetic Techniques |
| D002469 | Cell Separation |
| D003592 | Cytophotometry |
| D005470 | Fluorometry |
| D008163 | Luminescent Measurements |
| D010783 | Photometry |
| D002623 | Chemistry Techniques, Analytical |