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| ID | Type | Description | Link |
|---|---|---|---|
| VU-VICC-GI-0611 | |||
| VU-VICC-060479 |
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slow accrual
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This laboratory study is looking at biomarkers in stored tumor samples from younger patients with liver cancer.
OBJECTIVES:
OUTLINE: Archived tissue samples are collected from the pathology department at Vanderbilt University Medical Center and from the Mayo Clinic in Rochester, Minnesota. Tissue samples are analyzed by genomic analysis using array comparative genomic hybridization, target gene mutation analysis by PCR, and proteomic profiling on fixed tissues using various proteomic methods, including IHC and mass spectrometry. Samples are also examined for association between molecular aberrations and clinicopathologic features found in each disease.
Clinical patient data (i.e., age, sex, race, date of diagnosis, risk factors, histology, surgical staging, follow-ups, date of death, and adjuvant therapy) are also collected.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| comparative genomic hybridization | Genetic |
| ||
| molecular genetic technique | Genetic |
| ||
| mutation analysis | Genetic |
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| polymerase chain reaction | Genetic | Not noted |
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| proteomic profiling | Genetic |
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| immunohistochemistry staining method | Other | not noted |
| Measure | Description | Time Frame |
|---|---|---|
| Identification of proteomic profiles and molecular pathways involved in tumor progression | Genomic analysis, targeted gene mutation analysis, immunohistochemistry, and mass spectrometry will be employed to identify proteomic profiles and specific molecular pathways involved in tumor progression of fibrolamellar carcinoma and hepatocellular carcinoma | After collection of tissue samples |
| Measure | Description | Time Frame |
|---|---|---|
| Association between fibrolamellar carcinoma and hepatocellular carcinoma in terms of molecular aberrations and clinicopathologic features | Compare and contrast fibrolamellar carcinoma with hepatocellular carcinoma in terms of the molecular differences, tissue pathologies, and medical histories. | After molecular analysis of tissue and after collection of clinicopathologic data |
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Inclusion Criteria:
DISEASE CHARACTERISTICS:
Exclusion Criteria:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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Sample collection: 20 cases of fibrolamellar carcinoma and 20 hepatocellular carcinomas.
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| Name | Affiliation | Role |
|---|---|---|
| Laura Goff, MD | Vanderbilt-Ingram Cancer Center | Study Chair |
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DNA will be extracted from the tissue samples and analyzed for molecular signatures, i.e., genomic and proteomic analyses.
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| laboratory biomarker analysis | Other | not noted |
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| mass spectrometry | Other | not noted |
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| medical chart review | Other | not noted |
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| ID | Term |
|---|---|
| D008113 | Liver Neoplasms |
| D006528 | Carcinoma, Hepatocellular |
| ID | Term |
|---|---|
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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| ID | Term |
|---|---|
| D055028 | Comparative Genomic Hybridization |
| D005820 | Genetic Testing |
| D016133 | Polymerase Chain Reaction |
| D007150 | Immunohistochemistry |
| D013058 | Mass Spectrometry |
| ID | Term |
|---|---|
| D020732 | Cytogenetic Analysis |
| D005821 | Genetic Techniques |
| D008919 | Investigative Techniques |
| D025202 | Molecular Diagnostic Techniques |
| D009693 | Nucleic Acid Hybridization |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D033142 | Genetic Services |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
| D003954 | Diagnostic Services |
| D011314 | Preventive Health Services |
| D021141 | Nucleic Acid Amplification Techniques |
| D006651 | Histocytochemistry |
| D003584 | Cytological Techniques |
| D006652 | Histological Techniques |
| D007158 | Immunologic Techniques |
| D002623 | Chemistry Techniques, Analytical |
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