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| ID | Type | Description | Link |
|---|---|---|---|
| ECOG-E1496T1 |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors predict how patients respond to treatment.
PURPOSE: This laboratory study is looking at biomarkers in patients with stage III or stage IV follicular lymphoma treated on clinical trial E-1496.
OBJECTIVES:
OUTLINE: This is a multicenter study.
Tissue samples are analyzed by gene expression profiling, microarrays to predict gene expression, immunohistochemistry, and immunoglobulin Fc-gamma receptor polymorphism analysis for biological markers.
PROJECTED ACCRUAL: A total of 175 samples will be accrued for this study.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gene expression analysis | Genetic | |||
| microarray analysis | Genetic | |||
| polymorphism analysis | Genetic | |||
| diagnostic laboratory biomarker analysis | Other | |||
| immunohistochemistry staining method | Other | |||
| immunologic technique | Other |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of gene expression profiles with progression-free survival (PFS) | 1 month | |
| Prediction of PFS by immunoglobulin Fc-gamma receptor polymorphisms as assessed by immunohistochemistry | 1 month | |
| Assessment of significance of microenvironment by constructing tissue microarrays and immunostaining with relevant biomarkers | 1 month | |
| Correlation of relevant biomarkers with clinical features, response, and PFS | 1 month |
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DISEASE CHARACTERISTICS:
Diagnosis of follicular lymphoma
Received cyclophosphamide, vincristine, and prednisone with or without rituximab on clinical trial E-1496
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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Samples submitted for research from patients participating in E1496
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| Name | Affiliation | Role |
|---|---|---|
| Randall D. Gascoyne, MD | British Columbia Cancer Agency | Study Chair |
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| ID | Term |
|---|---|
| D008223 | Lymphoma |
| D008224 | Lymphoma, Follicular |
| ID | Term |
|---|---|
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D008228 | Lymphoma, Non-Hodgkin |
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| ID | Term |
|---|---|
| D020869 | Gene Expression Profiling |
| D046228 | Microarray Analysis |
| D054458 | Amplified Fragment Length Polymorphism Analysis |
| D007150 | Immunohistochemistry |
| D007158 | Immunologic Techniques |
| ID | Term |
|---|---|
| D005821 | Genetic Techniques |
| D008919 | Investigative Techniques |
| D046208 | Microchip Analytical Procedures |
| D016172 | DNA Fingerprinting |
| D016133 | Polymerase Chain Reaction |
| D021141 | Nucleic Acid Amplification Techniques |
| D006651 | Histocytochemistry |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006652 | Histological Techniques |
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