CompletedObservationalLast updated May 12, 2009

Analysis of the Clinical and Histological Correlation of Oral Graft-Versus-Host-Disease (GVHD)

Clinical and Histological Evaluation of Chronic Graft-Versus Host Disease (cGVHD) in Oral Mucosa

Overview

ClinicalTrials.gov ID: NCT00898885
Lead Sponsor: University of Sao PauloOTHER
Brief Summary: Introduction: Graft-versus-host-disease (GVHD) is the major cause of morbidity and mortality in patients submitted to the Bone Marrow Transplantation (BMT). The oral manifestations can be very debilitating and interfere in the results of medical therapy, leading to systemic complications, committing the prognosis and quality of life of the patient.

The early diagnosis can be done through biopsies of oral mucosa with or without apparent injury clinic. The association between the clinical and histopathological tables of GVHD, especially through the use of recent consensus established in these areas, can bring new benefits to physicians.

Objective: This study aims to apply and compare the two classifications histological to GVHD, Horn (1995) and Consensus (2006) in specimens obtained from clinical oral lesions suggestive of GVHD; correlate them with clinical classification according Akpek (2001) and with the survival of the patients.

Status

Overall Status: Completed
Start Date: Jan 2008
Primary Completion Date: Oct 2008Actual
Completion Date: Apr 2009Actual

Study Record Dates

First Submitted: May 11, 2009
First Submitted that Met QC Criteria: May 11, 2009
First Posted: May 12, 2009Estimated
Last Update Submitted that Met QC Criteria: May 11, 2009
Last Update Posted: May 12, 2009Estimated
Last Verified: May 2009

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