Identification of the Prognostic Factors of Stage II Colon Cancer Patients Receiving Adjuvant Chemotherapy With UFT
Identification of the Prognostic Factors of Stage II Colon Cancer Patients Receiving Adjuvant Chemotherapy With UFT
RATIONALE: Studying samples of tumor tissue in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict which patients will respond to treatment.
PURPOSE: This laboratory study is looking at prognostic factors in patients receiving tegafur-uracil for stage II colon cancer that was completely removed by surgery.
OBJECTIVES:
OUTLINE: Available tumor tissue samples are analyzed by real-time reverse transcriptase-PCR for TS, DPD, TP, OPRT, VEGF, cyclooxygenase-2, and FPGS; by PCR for microsatellite instability and genomic deletions on chromosome arm 18q; and pathologically for tumor budding, Crohn's-like lymphoid reaction, category of extent of poor differentiation, and fibrotic cancer stroma. The candidate prognostic and predictive markers are analyzed for correlation with disease-free survival, relapse-free survival, and overall survival of patients.
DISEASE CHARACTERISTICS:
Histologically confirmed adenocarcinoma of the colon or rectosigmoid
Must be registered on clinical trial TMDU-BRI-CC-05-01
Must have resected tumor tissue available
No hereditary colorectal cancer
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Inba-gunn, Chiba 270-1694, Japan
Yoshida-gun, Fukui 910-1193, Japan
Ogaki-shi, Gifu 503-8502, Japan
Otashi, Gunma 373-8550, Japan
Fukuyama, Hiroshima 721-8581, Japan
Otaru-shi, Hokkaido 047-0031, Japan
Akou, Hyōgo 678-0232, Japan
Takarazukai, Hyōgo 665-0873, Japan
Ibaraki, Ibaraki 311-3193, Japan
Ashigarakami-gun, Kanagawa 258-0003, Japan
Kumamoto, Kumamoto 860-8556, Japan
Kanigyou-ku, Kyoto 602-8026, Japan
Thu-shi, Mie-ken 514-8507, Japan
Yamatotakada, Nara 635-0022, Japan
Yufu-shi, Oita Prefecture 879-5593, Japan
Mino, Osaka 562-0014, Japan
Sakai-shi, Osaka 591-8025, Japan
Suita-shi, Osaka 564-0082, Japan
Kawagoe-shi, Saitama 350-8550, Japan
Izumo-shi, Shimane 693-0068, Japan
Shimotsuke-shi, Tochigi 329-0498, Japan
Chuo-ku, Tokyo 104-8560, Japan
Shinjuku-ku, Tokyo 169-0073, Japan
Shinjyuku-ku, Tokyo 162-8666, Japan
Takaoka-shi, Toyama 933-8555, Japan
Chu-o-shi, Yamanashi 409-3898, Japan