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| ID | Type | Description | Link |
|---|---|---|---|
| ECOG-E3200T2 |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors understand how patients respond to treatment.
PURPOSE: This laboratory study is looking at gene expression in patients with advanced or metastatic colorectal cancer receiving bevacizumab.
OBJECTIVES:
OUTLINE: Tumor tissue samples collected on clinical trial E-3200 are analyzed for laboratory endpoints.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gene expression analysis | Genetic | |||
| protein expression analysis | Genetic | |||
| reverse transcriptase-polymerase chain reaction | Genetic | |||
| immunoenzyme technique | Other | |||
| immunohistochemistry staining method | Other | |||
| immunologic technique | Other |
| Measure | Description | Time Frame |
|---|---|---|
| Mean scores for VEGFb and pan-VEGF gene expression by IHC | 1 month | |
| Gene expression as measured by tissue microarrays | 1 month | |
| Splice form expression as measured by reverse transcriptase-PCR | 1 month | |
| VEGF165b protein expression as measured by ELISA | 1 month |
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DISEASE CHARACTERISTICS:
Tumor tissue samples available from patients with advanced or metastatic adenocarcinoma of the colon or rectum
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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Samples submitted for research from patients participating in E3200
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| Name | Affiliation | Role |
|---|---|---|
| David Bates, PhD | Bristol Heart Institute at University of Bristol | Study Chair |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D003110 | Colonic Neoplasms |
| D012004 | Rectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
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| ID | Term |
|---|---|
| D020869 | Gene Expression Profiling |
| D020133 | Reverse Transcriptase Polymerase Chain Reaction |
| D007124 | Immunoenzyme Techniques |
| D007150 | Immunohistochemistry |
| D007158 | Immunologic Techniques |
| ID | Term |
|---|---|
| D005821 | Genetic Techniques |
| D008919 | Investigative Techniques |
| D016133 | Polymerase Chain Reaction |
| D021141 | Nucleic Acid Amplification Techniques |
| D007118 | Immunoassay |
| D015336 | Molecular Probe Techniques |
| D006651 | Histocytochemistry |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006652 | Histological Techniques |
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