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| ID | Type | Description | Link |
|---|---|---|---|
| P30CA022453 | U.S. NIH Grant/Contract | View source | |
| WSU-C-2737 | |||
| WSU-013105MP2E |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
PURPOSE: This laboratory study is examining blood samples from patients with cancer to identify biomarkers that may help in the early detection of pancreatic cancer.
OBJECTIVES:
OUTLINE: Blood from patients is collected prior to treatment. Plasma proteins are analyzed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS) and/or electrospray mass spectrometry (ESI/MS).
PROJECTED ACCRUAL: A total of 120 patients will be accrued for this study.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| protein expression analysis | Genetic | Venous blood collection | ||
| laboratory biomarker analysis | Other | Venous blood collection | ||
| mass spectrometry | Other | Venous blood collection | ||
| surface-enhanced laser desorption/ionization-time of flight mass spectrometry | Other | Venous blood collection |
| Measure | Description | Time Frame |
|---|---|---|
| Identification of specific proteins of interest to evaluate for their potential role as markers for pancreatic cancer | Upon collection when patient agrees to provide a one time venous blood collection | |
| Analysis of serum proteins directly by mass spectrometry to identify new biomarkers of pancreatic cancer that can be used for early diagnosis | After separation from the plasma |
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DISEASE CHARACTERISTICS:
Diagnosis of pancreatic cancer
Planning to undergo surgery or other treatment for pancreatic cancer at Karmanos Cancer Institute or its affiliates
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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Venous blood collection samples from newly dianosed
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| Name | Affiliation | Role |
|---|---|---|
| Fazlul Sarkar, MD | Barbara Ann Karmanos Cancer Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201-1379 | United States |
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| ID | Term |
|---|---|
| D010190 | Pancreatic Neoplasms |
| ID | Term |
|---|---|
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004701 | Endocrine Gland Neoplasms |
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| ID | Term |
|---|---|
| D013058 | Mass Spectrometry |
| D019032 | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
| ID | Term |
|---|---|
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
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Venous blood
| D004066 |
| Digestive System Diseases |
| D010182 | Pancreatic Diseases |
| D004700 | Endocrine System Diseases |