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| ID | Type | Description | Link |
|---|---|---|---|
| CALGB-20801 | |||
| CDR0000595708 | Registry Identifier | NCI Physician Data Query | |
| NCI-2009-00462 | Registry Identifier | NCI Clinical Trials Reporting Program |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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RATIONALE: Studying samples of blood and bone marrow in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and identify genes related to cancer. It may also help doctors diagnose cancer and predict how patients will respond to treatment.
PURPOSE: This research study is identifying cancer-related genes in blood and/or bone marrow samples from patients with acute myeloid leukemia.
OBJECTIVES:
OUTLINE: Blood and/or bone marrow samples previously procured from patients on CALGB-9665 are obtained from the CALGB Leukemia Tissue Bank from patients enrolled on CALGB AML treatment studies. Mononuclear cells are isolated from samples and mRNA is extracted. Gene expression profiles are analyzed via custom mRNA microarray and confirmed by quantitative real-time PCR.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | This is a CALGB Leukemia Tissue Bank project makes use of tissue from patients who have previously provided their consent. Diagnostic samples from patients enrolled on CALGB AML treatment studies (eg, CALGB 9621, 9710, and 19808) and who have been registered on the companion Leukemia Tissue Bank Protocol CALGB 9665 were used. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| microarray analysis | Genetic |
| ||
| polymerase chain reaction |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of increased or decreased expression of same transcripts with disease outcome | baseline | |
| Minimum number of genes that can be used for precise diagnosis of each of the three subtypes of acute myeloid leukemia | baseline | |
| Identification of individual genes that are differentially expressed between the subtypes of AMLs | baseline | |
| Correlation of the patterns of expression of the translocation-specific transcripts with age, sex, race, response to treatment, survival, and with other known mutations | baseline |
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Enrolled on CALGB acute myeloid leukemia (AML) treatment studies AND concurrently enrolled on Leukemia Tissue Bank Protocol CALGB-9665
Short-term or long-term survivor
Bone marrow and/or peripheral blood obtained at diagnosis
Leukemia is one of the following cytogenetic subtypes:
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Patients diagnosed with acute myeloid leukemia.
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| Name | Affiliation | Role |
|---|---|---|
| Janet Rowley, MD | University of Chicago | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fort Wayne Medical Oncology and Hematology | Fort Wayne | Indiana | 46845 | United States | ||
| Wayne Memorial Hospital, Incorporated |
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| ID | Term |
|---|---|
| D007938 | Leukemia |
| D015470 | Leukemia, Myeloid, Acute |
| ID | Term |
|---|---|
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| ID | Term |
|---|---|
| D046228 | Microarray Analysis |
| D016133 | Polymerase Chain Reaction |
| ID | Term |
|---|---|
| D046208 | Microchip Analytical Procedures |
| D008919 | Investigative Techniques |
| D021141 | Nucleic Acid Amplification Techniques |
| D005821 | Genetic Techniques |
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Bone marrow and/or peripheral blood obtained at diagnosis from AML patients enrolled on CALGB AML treatment studies.
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| Goldsboro |
| North Carolina |
| 27534 |
| United States |
| D007951 | Leukemia, Myeloid |