A Trial Investigating the Possible Difference in Development of Type 2 Diabetes Between Caucasian and Japanese Subjects

A Trial Investigating the Possible Difference in the Development of Type 2 Diabetes in Caucasian and Japanese Subjects by a Model-based Analysis

This trial is conducted in Europe and Japan. The aim of this clinical trial is to investigate the possible difference in the development of type 2 diabetes in a Japanese and a Caucasian population. Healthy subjects, subjects with impaired glucose tolerance, as well as subjects with type 2 diabetes will be included in the trial. The development of type 2 diabetes across the cohort will be investigated with regard to insulin sensitivity and B-cell capacity.

Inclusion Criteria:

• Danish (Northern European) or Japanese (according to country allocation) background for at least 3 generations
• BMI above or equal to 18 kg/m2

Exclusion Criteria:

• Treatment of diabetes mellitus with any insulin product
• Fasting plasma/serum glucose above 12 mM
• Therapy with TZD (thiazolidinedione) drugs within the past 3 months
• Therapy with more than 2 OADs (oral anti-diabetics drugs)