Factors Influencing Anesthetic Drug Requirement

Impact of Environmental and Demographic Factors on Pre-operative Doses of Anesthetic Agents (Prospective Multicenter Study)

The main objective of the study is to analyze the influence of several environmental (i.e., timing: seasonal, circadian) and demographic conditions (i.e., age, gender, menstrual cycle) on anesthetic drug requirements (hypnotic and opiate).

Inclusion Criteria:

• Patients undergoing scheduled surgery under general anesthesia, agreeing to participate in the study

Exclusion Criteria:

• Age under 18 years
• Pregnancy, breastfeeding woman
• Allergy to propofol, soybeans or peanuts
• Allergy to sufentanil, remifentanil, morphine,
• Allergy to a muscle relaxant or to any of its excipients
• Known hypersensitivity to sufentanil, remifentanil, or to other derivates of fentanyl
• History of central neurological disorder or brain injury
• Patient with dementia
• Patient with pacemaker
• Patient receiving psychotropic drugs or morphine agonist-antagonists
• Surgery on the skull and/or operating position preventing the use of a bispectral index sensor in suitable conditions