Transdermal Contraceptive Patch - Endometrial Effects Study

Single-center,Open-label, Uncontrolled Study to Investigate the Effects of the Transdermal Contraceptive Patch Containing 0.55 mg Ethinylestradiol and 2.1 mg Gestodene on the Endometrium in a 21-day Regimen for 13 Cycles in 80 Healthy Women

The aim of the present study is to investigate the effects of the transdermal patch on the endometrium in healthy women who require contraception.

Inclusion Criteria:

• Requiring contraception
• Normal cervical smear
• Smokers not older than 30 years
• History of regular cyclic menstrual periods

Exclusion Criteria:

• Pregnancy or lactation
• Obesity (BMI> 30 kg/m2)
• Significant skin reaction to transdermal preparations or sensitivity to surgical / medical tape
• Any disease that may worsen under hormonal treatment (cardiovascular, liver, metabolic)
• Use of other contraceptive methods than study medication