Levocetirizine Effect on Nasal Nitric Oxide and Nasal Eosinophils in Subjects With Perennial Allergic Rhinitis

Levocetirizine Effect on Nasal Nitric Oxide and Nasal Eosinophils in Subjects With Perennial Allergic Rhinitis

The purpose of this study is to noninvasively measure the anti-inflammatory effect of levocetirizine after two weeks of treatment in allergic rhinitis subjects.

Inclusion Criteria:

• ICF signed
• Diagnosis of PAR for 6-12 months greater
• 12 years and older
• Decreased nasal NO values at baseline
• Compliance and ability to perform maneuvers and responsibilities

Exclusion Criteria:

• Oral or systemic steroids for 60 days prior
• Inhaled, nasal, nebulized steroids w/i 4 weeks
• Hospitalization or life threatening asthma
• Use of nasal or oral antihistamines w/i 4 weeks
• Upper or lower airways infection
• Direct cigarette smoke exposure