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| ID | Type | Description | Link |
|---|---|---|---|
| R21DA025794 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Food and Drug Administration (FDA) | FED |
| National Institute on Drug Abuse (NIDA) | NIH |
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Heavy marijuana users report experiencing trouble sleeping when they try to quit, but this has not been carefully studied. This research is being done to learn more about sleep function in heavy marijuana users, and to determine whether a medication approved for treating insomnia can help restore normal sleep function during brief periods of abstinence.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active Medication | Experimental | Participants receive active hypnotic medication prior to sleep |
|
| Placebo | Placebo Comparator | Participants receive placebo prior to sleep |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| eszopiclone | Drug | Oral capsule at dose recommended for adults |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Marijuana Withdrawal | Every day during study participation |
| Measure | Description | Time Frame |
|---|---|---|
| Objective Sleep Assessment | Every day during study participation | |
| Cognitive Performance | Every day during study participation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ryan Vandrey, Ph.D. | Johns Hopkins University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johns Hopkins University | Baltimore | Maryland | 21224 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21359104 | Derived | Vandrey R, Umbricht A, Strain EC. Increased blood pressure after abrupt cessation of daily cannabis use. J Addict Med. 2011 Mar;5(1):16-20. doi: 10.1097/ADM.0b013e3181d2b309. | |
| 21296508 | Derived | Vandrey R, Smith MT, McCann UD, Budney AJ, Curran EM. Sleep disturbance and the effects of extended-release zolpidem during cannabis withdrawal. Drug Alcohol Depend. 2011 Aug 1;117(1):38-44. doi: 10.1016/j.drugalcdep.2011.01.003. Epub 2011 Feb 5. |
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| ID | Term |
|---|---|
| D002189 | Marijuana Abuse |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000069582 | Eszopiclone |
| C495910 | ramelteon |
| D000077334 | Zolpidem |
| ID | Term |
|---|---|
| D010879 | Piperazines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D011719 | Pyrazines |
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| Placebo |
| Drug |
Participants receive placebo prior to sleep |
|
| ramelteon | Drug | ramelteon |
|
| zolpidem | Drug | zolpidem |
|
| D011725 |
| Pyridines |