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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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The purpose of this study is to determine whether respiratory viral infections increase the risk of bronchiolitis obliterans syndrome (BOS), obliterative bronchiolitis (OB), death, or retransplantation in children who have received lung transplants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pediatric lung transplantation |
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| Measure | Description | Time Frame |
|---|---|---|
| The earliest time to BOS or OB, retransplantation or death | Within 24 months of transplant |
| Measure | Description | Time Frame |
|---|---|---|
| Time to each of the following events: BOS or OB, retransplantation or death | Within 24 months of transplant |
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Inclusion Criteria:
Exclusion Criteria:
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Pediatric patients undergoing lung transplantation
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| Name | Affiliation | Role |
|---|---|---|
| Stuart Sweet, MD, PhD | Washington University School of Medicine | Principal Investigator |
| Lara Danziger-Isakov, MD, MPH | Children's Hospital Medical Center, Cincinnati | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University | Palo Alto | California | 94305 | United States | ||
| Children's Hospital Boston |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19176714 | Background | Hayes D Jr, Ballard HO. Saber-sheath trachea in a patient with bronchiolitis obliterans syndrome after lung transplantation. Chron Respir Dis. 2009;6(1):49-52. doi: 10.1177/1479972308099990. | |
| 19131537 | Background | Sweet SC. Pediatric lung transplantation. Proc Am Thorac Soc. 2009 Jan 15;6(1):122-7. doi: 10.1513/pats.200808-095GO. |
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| ID | Term |
|---|---|
| D001989 | Bronchiolitis Obliterans |
| D008171 | Lung Diseases |
| ID | Term |
|---|---|
| D001988 | Bronchiolitis |
| D001991 | Bronchitis |
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
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Blood and nasopharyngeal samples
| Boston |
| Massachusetts |
| United States |
| Washington University | St Louis | Missouri | 63110 | United States |
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | United States |
| Children's Hospital of Pennsylvania | Philadelphia | Pennsylvania | 19104 | United States |
| Texas Children's Hospital | Houston | Texas | 77030 | United States |
| 19191770 | Background | Vos R, Vanaudenaerde BM, De Vleeschauwer SI, Van Raemdonck DE, Dupont LJ, Verbeken EK, De Wever W, Verleden GM. Follicular bronchiolitis: a rare cause of bronchiolitis obliterans syndrome after lung transplantation: a case report. Am J Transplant. 2009 Mar;9(3):644-50. doi: 10.1111/j.1600-6143.2008.02518.x. Epub 2009 Feb 3. |
| 19202534 | Background | Yun JJ, Mason DP. Lung transplantation: past, present, and future. Minerva Chir. 2009 Feb;64(1):37-44. |
| 31216376 | Result | Sweet SC, Chin H, Conrad C, Hayes D Jr, Heeger PS, Faro A, Goldfarb S, Melicoff-Portillo E, Mohanakumar T, Odim J, Schecter M, Storch GA, Visner G, Williams NM, Kesler K, Danziger-Isakov L. Absence of evidence that respiratory viral infections influence pediatric lung transplantation outcomes: Results of the CTOTC-03 study. Am J Transplant. 2019 Dec;19(12):3284-3298. doi: 10.1111/ajt.15505. Epub 2019 Jul 25. |
| D008173 |
| Lung Diseases, Obstructive |