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The perioperative administration of n-3 fatty acids has been shown to lead to favorable effects on outcome in patients with severe surgical interventions by lowering the magnitude of inflammatory response and by modulating the immune response. To the investigators' knowledge, no study with preoperative administration of intravenous (IV) omega 3 fatty acids as a part of total parenteral nutrition (TPN) or monotherapy with it to demonstrate its effects on inflammatory and immune response has been conducted. So, this study has been planned to judge the inflammatory response of preoperative monotherapy with IV omega 3 fatty acids in elderly patients undergoing valvular surgery considering the hyperinflammation associated with this type of surgery in elderly patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Omegaven | Active Comparator | will receive IV Omega 3 fatty acids (Omegaven®) for 3 days preoperatively |
|
| Without Omegaven | No Intervention | will not receive IV Omega 3 fatty acids (Omegaven®) for 3 days preoperativel |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Omegaven-IV FO | Dietary Supplement | will receive IV Omega 3 fatty acids (Omegaven®) for 3 pre operative days |
|
| Measure | Description | Time Frame |
|---|---|---|
| IL-6, 8, 10, HS-CRP | 5 days |
| Measure | Description | Time Frame |
|---|---|---|
| Infectious complications | 5 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dr R Gopinath | Professor and Head, Department of ANesthesia and critical care | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| NIzam's Institute of Medical Sciences | Hyderabad | Andhra Pradesh | India |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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