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no patients to include
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Multi-organ failure due to sepsis is a major cause of death in critically ill patients. But the mechanisms leading to this condition are not fully understood. Mitochondrial dysfunction has been shown in skeletal muscle of critically ill septic patients. Liver is very important in sepsis as it is responsible of the synthesis of several inflammatory proteins. Moreover hepatic failure is associated to a bad outcome.
The aim of this study is to evaluate the hepatic mitochondrial function in sepsis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Non septic patients needing hepatic surgery | ||
| Sepsis | Septic patients needing surgery for peritonitis |
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| Measure | Description | Time Frame |
|---|---|---|
| Mitochondrial complex activities | during surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Quantification of adenine nucleotides | during surgery | |
| Quantification of oxidative stress markers | during surgery | |
| Correlation between SOFA score and mitochondrial complex activities |
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Inclusion Criteria:
Exclusion Criteria:
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Community sample
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| Name | Affiliation | Role |
|---|---|---|
| Carole Ichai, MD, PhD | Centre Hospitalier Universitaire de Nice | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nice | Nice | 06003 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12133657 | Background | Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, Davies NA, Cooper CE, Singer M. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet. 2002 Jul 20;360(9328):219-23. doi: 10.1016/S0140-6736(02)09459-X. | |
| 16803854 | Background | Fredriksson K, Hammarqvist F, Strigard K, Hultenby K, Ljungqvist O, Wernerman J, Rooyackers O. Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1044-50. doi: 10.1152/ajpendo.00218.2006. Epub 2006 Jun 27. |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| D010538 | Peritonitis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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Liver biopsies
| 28 days |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D059413 | Intraabdominal Infections |
| D010532 | Peritoneal Diseases |
| D004066 | Digestive System Diseases |