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The purpose of this study is to evaluate the yield of endoscopic guided fine needle aspirations (by means of transoesophageal endoscopic ultrasound : EUS-FNA or transbronchial endoscopic ultrasound : EBUS-TBNA) in patients with a clinical suspicion for sarcoidosis stage I-II; but in whom the preceding bronchoscopy did not result in a qualifying diagnosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bronchoscopy | Experimental | Bronchoscopy, only if no diagnosis is obtained, patients go for EUS-FNA or EBUS-TBNA, only if no diagnosis is obtained, patients go for surgical biopsy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bronchoscopy | Procedure | Bronchoscopy, only if no diagnosis is obtained, patients go for EUS-FNA or EBUS-TBNA, only if no diagnosis is obtained, patients go for surgical biopsy |
|
| Measure | Description | Time Frame |
|---|---|---|
| The diagnostic yield of state-of-the art bronchoscopy (including TBB, EBB and TBNA) | At the end of study | |
| The role of endosonography (EUS-FNA or EBUS-TBNA) in demonstrating non-caseating granulomas after a non-qualifying bronchoscopy | At the end of study |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of sarcoidosis and alternate diagnosis | At the end of study | |
| Stage distribution | At the end of study | |
| Complication rate of each type of procedure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kurt G. Tournoy, Md, PhD | University Hospital, Ghent | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| OLV Ziekenhuis Aalst | Aalst | Belgium | ||||
| Universitair Ziekenhuis Antwerpen |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19897553 | Derived | Tournoy KG, Bolly A, Aerts JG, Pierard P, De Pauw R, Leduc D, Leloup A, Pieters T, Slabbynck H, Janssens A, Carron K, Schrevens L, Pat K, De Keukeleire T, Dooms C. The value of endoscopic ultrasound after bronchoscopy to diagnose thoracic sarcoidosis. Eur Respir J. 2010 Jun;35(6):1329-35. doi: 10.1183/09031936.00111509. Epub 2009 Nov 6. |
| Label | URL |
|---|---|
| Website of the University Hospital Ghent | View source |
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| ID | Term |
|---|---|
| D012507 | Sarcoidosis |
| ID | Term |
|---|---|
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006968 | Hypersensitivity, Delayed |
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| ID | Term |
|---|---|
| D001999 | Bronchoscopy |
| ID | Term |
|---|---|
| D003948 | Diagnostic Techniques, Respiratory System |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D004724 | Endoscopy |
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| At the end of study |
| Cost to obtain a qualifying diagnosis with this strategy in this population | At the end of study |
| Antwerp |
| Belgium |
| ZNA Antwerpen | Antwerp | Belgium |
| AZ St. Jan Hospitaal Brugge | Bruges | Belgium |
| Cliniques Universitaires St. Luc | Brussels | Belgium |
| Höpital Erasme Brussel | Brussels | Belgium |
| University Hospital Brussels | Brussels | Belgium |
| CHU Charleroi | Charleroi | Belgium |
| University Hospital Ghent | Ghent | 9000 | Belgium |
| Virga Jesse Hospitaal | Hasselt | Belgium |
| UZ Gasthuisberg Leuven | Leuven | Belgium |
| Heilig Hartziekenhuis Menen | Menen | Belgium |
| Hôpital Saint Elisabeth Namur | Namur | Belgium |
| AZ Oudenaarde | Oudenaarde | Belgium |
| Ampha Ziekenhuis Breda | Breda | Netherlands |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D003949 | Diagnostic Techniques, Surgical |
| D019060 | Minimally Invasive Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D013510 | Pulmonary Surgical Procedures |
| D019616 | Thoracic Surgical Procedures |