Minimally Invasive Techniques Or Surgery In the Diagnosis of Sarcoidosis

Minimally Invasive Techniques Or Surgery In the Diagnosis of Sarcoidosis (MITOSIS-Trial)

The purpose of this study is to evaluate the yield of endoscopic guided fine needle aspirations (by means of transoesophageal endoscopic ultrasound : EUS-FNA or transbronchial endoscopic ultrasound : EBUS-TBNA) in patients with a clinical suspicion for sarcoidosis stage I-II; but in whom the preceding bronchoscopy did not result in a qualifying diagnosis.

Inclusion Criteria:

• Age ≥ 18 y
• Suspicion of thoracic sarcoidosis and need for tissue confirmation
• Recent (<6 weeks) RX and CT-thorax (HRCT not compulsory)
• Fit for bronchoscopy (with or without EBB, TBB, TBNA), esophagoscopy and surgery
• Written informed consent

Exclusion Criteria:

• Patients with obvious other organ involvement allowing "simple and safe" biopsy
• Lofgren syndrome
• Pregnancy