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| Name | Class |
|---|---|
| National Cancer Plan, France | UNKNOWN |
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84 patients with a cup size C or more will be randomized to receive intensity-modulated radiotherapy in supine or prone position.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | prone intensity-modulated radiotherapy |
|
| 2 | Active Comparator | supine intensity-modulated radiotherapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| radiation in prone position | Behavioral | radiation in prone position |
| |
| Measure | Description | Time Frame |
|---|---|---|
| acute moist desquamation | weekly during radiotherapy and 1 month after radiotherapy |
| Measure | Description | Time Frame |
|---|---|---|
| Acute skin toxicity other than moist desquamation | weekly during radiotherapy and 1 month after radiotherapy | |
| Late skin toxicity | at 6, 12, 18 and 24 months after radiotherapy | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wilfried De Neve, MD, PhD | University Hospital, Ghent | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Ghent | Ghent | 9000 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33508375 | Derived | Vakaet V, Van Hulle H, Vergotte M, Schoepen M, Deseyne P, Van Greveling A, Post G, Speleers B, Paelinck L, Monten C, De Neve W, Veldeman L. 5-Year Outcomes of a Randomized Trial Comparing Prone and Supine Whole Breast Irradiation in Large-Breasted Women. Int J Radiat Oncol Biol Phys. 2021 Jul 1;110(3):766-771. doi: 10.1016/j.ijrobp.2021.01.026. Epub 2021 Jan 27. |
| Label | URL |
|---|---|
| website of the University Hospital Ghent | View source |
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| radiation in supine position |
| Behavioral |
radiation in supine position |
|
| skin and lung fibrosis assessed with computed tomography |
| before radiotherapy and 1 month and 1 year after radiotherapy |
| Quality of life | at 1 year and 2 years after radiotherpay |
| dose-volume parameters | of planning |
| time of treatment delivery | daily during radiotherapy |
| single nucleotide polymorphisms associated with skin toxicity and breast fibrosis | 1 blood sample before radiotherapy |
| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| D011827 | Radiation |
| D016684 | Prone Position |
| D016683 | Supine Position |
| ID | Term |
|---|---|
| D055585 | Physical Phenomena |
| D011187 | Posture |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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