Trial Comparing Prone and Supine Intensity-modulated Radiotherapy (IMRT) After Breast-conserving Surgery in Patients With Large Breast Volume at High Risk for Skin Toxicity and Fibrosis

Randomized Controlled Trial Comparing Prone and Supine Intensity-modulated Radiotherapy (IMRT) After Breast-conserving Surgery in Patients With Large Breast Volume at High Risk for Skin Toxicity and Fibrosis

84 patients with a cup size C or more will be randomized to receive intensity-modulated radiotherapy in supine or prone position.

Inclusion Criteria:

• female patients
• multidisciplinary decision of adjuvant whole-breast irradiation (WBI) after lumpectomy for breast cancer
• minimum 18 years
• informed consent obtained, signed and dated before specific protocol procedures

Exclusion Criteria:

• mastectomy
• need for axillary irradiation
• bilateral breast irradiation
• previous irradiation at the same time
• mental condition rendering the patient unable to understand the nature, scope and possible consequences of the study
• patient unlikely to comply with the protocol; i.e. uncooperative attitude, inability to return for follow-up visits, and unlikely to complete the study.