Study to Proof the Clinical and Bacteriological Non-inferiority of Ampicillin/Amoxicillin Versus Moxifloxacin in Hospitalized Patients With Non-severe Community-acquired Pneumonia

Prospective, Doubleblind, Randomized Multicenter Study to Proof the Clinical and Bacteriological Non-inferiority of Ampicillin/Amoxicillin Versus Moxifloxacin in Hospitalized Patients With Non-severe Community-acquired Pneumonia

The purpose of this study is to prove the clinical and bacteriological non-inferiority of ampicillin/amoxicillin versus moxifloxacin in hospitalized patients with non-severe community-acquired pneumonia.

Inclusion Criteria:

• Men or women older than 18 years with signed informed consent

• Women in a childbearing age with sufficient conception protection or if necessary negative pregnancy test

• Infiltrates appeared newly in the x-ray thorax

• Breath-conditioned chest pain

• At least two of the following clinical symptoms of a pneumonia:

  • cough which is newly appeared or increasing,
  • dyspnea
  • mucopurulent or purulent sputum,
  • fever (body temperature >= 37.8 degrees Celsius auricalary and/or >= 38,3°C rectal), positive auscultation

• Negative legionella antigen test in the urine

• CRB-65-Index < 3

Exclusion Criteria:

• Hospitalization within the last 28 days (except for the last 72 h)
• Participation in another therapy study within the last 4 weeks with studies admission
• intake of an antibiotic longer than 24 hrs within the last 72 hours before studies admission
• Patients in the pregnancy and nursing phase
• Existence of contraindications opposite the examining preparations or other B-Lactam antibiotics or fluorochinolons
• Patients with a CURB-Index >= 3
• Patients with suspicion of retrostenotic Pneumonia because of bronchial obstruction
• Patients with suspicion of nosocomial Pneumonia
• Patients with an infection by a known or suspected resistant pathogene