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| Name | Class |
|---|---|
| Heart and Stroke Foundation of Canada | OTHER |
| Canadian Institutes of Health Research (CIHR) | OTHER_GOV |
| Canadian Stroke Network | OTHER |
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The objective of the Program of Rehabilitative Exercise and Education to avert Vascular Events after Non-disabling stroke and Transient ischemic attack (PREVENT) Trial is to determine whether the timely delivery of secondary stroke prevention strategies will reduce modifiable vascular risk factors in two groups of people who have survived NDS or TIA. One group will receive a comprehensive education and exercise program (PREVENT); the other group will receive usual care (USUAL CARE). We will measure modifiable vascular risk factors in both groups. We will also compare the effects of PREVENT vs USUAL CARE on exercise capacity, walking endurance, and daily physical activity. In addition, we will compare thinking ability, depression, achievement of personal goals for healthy behavior, and health-related goal attainment and health-related quality of life. Finally, we will compare outcomes in urban and rural settings as well as costs of the PREVENT program and USUAL CARE in order to assess sustainability of the PREVENT program.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PREVENT program | Experimental | 12-week program of exercise and education to induce physiological and behavioral changes needed to reduce vascular risk factors. |
|
| Usual Care | Active Comparator | Average of three visits to the Neurovascular Clinic for a neurological and health assessment, counseling regarding stroke/TIA and diagnostic test results, and assessment, modification and education of secondary prevention factors |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PREVENT program | Behavioral | 12-week program of aerobic/strengthening exercises and education designed to induce physiological and behavioral changes deemed necessary to reduce vascular risk |
| Measure | Description | Time Frame |
|---|---|---|
| systolic blood pressure (primary vascular risk factor being assessed) | baseline, post-intervention, 6 months, 12 months | |
| diastolic blood pressure | baseline, post-intervention, 6 months, 12 months | |
| waist circumference | baseline, post-intervention, 6 months, 12 months | |
| 12-hour fasting lipid profile | baseline, post-intervention, 6 months, 12 months | |
| 12-hour fasting glucose/hemoglobin A1C | baseline, post-intervention, 6 months, 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| exercise capacity | baseline, post-intervention, 12 months | |
| daily physical activity | baseline, post-intervention, 6 months, 12 months | |
| walking endurance |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marilyn MacKay-Lyons, PhD | Dalhousie University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Halifax Infirmary Site, QEII Health Sciences Centre | Halifax | Nova Scotia | B3H 3A7 | Canada | ||
| Annapolis Valley Regional Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34788569 | Derived | MacKay-Lyons M, Gubitz G, Phillips S, Giacomantonio N, Firth W, Thompson K, Theriault C, Wightman H, Slipp S, Marsters D, Eskes G, Peacock F, Blanchard C, Dewolfe J. Program of Rehabilitative Exercise and Education to Avert Vascular Events After Non-Disabling Stroke or Transient Ischemic Attack (PREVENT Trial): A Randomized Controlled Trial. Neurorehabil Neural Repair. 2022 Feb;36(2):119-130. doi: 10.1177/15459683211060345. Epub 2021 Nov 17. | |
| 21143864 |
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| Usual Care | Behavioral | Three or more out-patient visits to the neurovascular clinic for assessment, counseling and referral to appropriate health care professionals. |
|
| baseline, post-intervention, 6 months, 12 months |
| cigarette smoking | baseline, post-intervention, 6 months, 12 months |
| medication adherence | baseline, post-intervention, 6 months, 12 months |
| cognition | baseline, 12 months |
| depression | baseline, post-intervention, 6 months, 12 months |
| health-related quality of life | baseline, post-intervention, 6 months, 12 months |
| health-related goal attainment | baseline, post-intervention, 6 months, 12 months |
| direct health costs | baseline, post-intervention, 6 months, 12 months |
| secondary vascular events | baseline, post-intervention, 6 months, 12 months |
| daily step count | baseline, post-intervention, 12 months |
| Kentville |
| Nova Scotia |
| B4N 5E3 |
| Canada |
| Derived |
| MacKay-Lyons M, Gubitz G, Giacomantonio N, Wightman H, Marsters D, Thompson K, Blanchard C, Eskes G, Thornton M. Program of rehabilitative exercise and education to avert vascular events after non-disabling stroke or transient ischemic attack (PREVENT Trial): a multi-centred, randomised controlled trial. BMC Neurol. 2010 Dec 8;10:122. doi: 10.1186/1471-2377-10-122. |
| ID | Term |
|---|---|
| D002546 | Ischemic Attack, Transient |
| D020521 | Stroke |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D002545 | Brain Ischemia |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D001519 | Behavior |
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