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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA026014 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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This study will examine the effectiveness of a brief intervention in a primary care setting to reduce drug use or abuse compared to enhanced care as usual.
A substantial body of research has established the efficacy and effectiveness of brief interventions (BI) for excessive or "hazardous" alcohol use in patients seen in medical settings. Dissemination projects of brief interventions for alcohol and drugs have recently been implemented on a widespread scale. This rapid progression of brief intervention for drugs other than alcohol has outstripped its evidence base.
The aims of the study as outlined in the grant are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Brief intervention using motivational interviewing. One in-person session (30-45 minutes) with a brief phone follow-up one week later. |
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| 2 | No Intervention | Enhanced care as usual. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Brief intervention using motivational interviewing | Behavioral | One brief, in-person motivational interviewing session (30-45 minutes) in conjunction with the medical appointment. Plus one brief follow-up phone call one week later. |
| Measure | Description | Time Frame |
|---|---|---|
| Use of illicit drugs in the past 30 days | Use of illicit drugs in the past 30 days will be measured by self-reported days of use in the past 30 days and validated by urine toxicological screen. | baseline, 3, 6, 9, and 12 months |
| Enrollment in formal substance abuse treatment | Enrollment in formal substance abuse treatment will be measured as an admission to chemical dependency treatment as recorded in the Washington State TARGET database. | baseline up to 2 years post-intervention |
| Medical, legal, employment, social, and psychiatric outcomes | Medical, legal, employment, social, and psychiatric outcomes will be measured by composite scores on the Addiction Severity Index (ASI) Lite. | baseline, 3, 6, 9, and 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Public health outcomes | Public health outcomes will be measured by administrative data sources (emergency room visits, hospitalizations, hospital days, HIV risk behavior, arrests, and death). | baseline up to 2 years post-intervention |
| Cost of the intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Peter P Roy-Byrne, MD | University of Washington | Principal Investigator |
| Kristin Bumgardner, BS | University of Washington | Study Director |
| Antoinette Krupski, PhD | University of Washington | Study Chair |
| Richard Ries, MD | University of Washington | Study Chair |
| Chris Dunn, PhD | University of Washington | Study Chair |
| Dennis Donovan, PhD | University of Washington | Study Chair |
| Jutta M. Joesch, PhD | University of Washington | Study Chair |
| Gary A. Zarkin, PhD | RTI International | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Harborview Medical Center | Seattle | Washington | 98104 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23237456 | Background | Krupski A, Joesch JM, Dunn C, Donovan D, Bumgardner K, Lord SP, Ries R, Roy-Byrne P. Testing the effects of brief intervention in primary care for problem drug use in a randomized controlled trial: rationale, design, and methods. Addict Sci Clin Pract. 2012 Dec 14;7(1):27. doi: 10.1186/1940-0640-7-27. | |
| 25096689 | Result | Roy-Byrne P, Bumgardner K, Krupski A, Dunn C, Ries R, Donovan D, West II, Maynard C, Atkins DC, Graves MC, Joesch JM, Zarkin GA. Brief intervention for problem drug use in safety-net primary care settings: a randomized clinical trial. JAMA. 2014 Aug 6;312(5):492-501. doi: 10.1001/jama.2014.7860. |
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| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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Cost of the intervention will be measured using methods previously employed in the COMBINE study. |
| baseline up to 2 years post-intervention |
| Incremental cost-effectiveness | Incremental cost-effectiveness will be measured from the payer perspective based on health care service use and drug use frequency. | baseline up to 2 years post-intervention |