The study is designed to assess the feasibility of evaluating YSPSL for the amelioration of ischemia reperfusion injury following liver transplantation by administering YSPSL into the liver graft directly ex vivo via the portal vein and to the recipient intravenously prior to reperfusion. This study is an extension of the recent pilot study YSPSL-0002 with an almost identical study protocol. The rationale of this and the previous study is based on the recent observation that P-selectin expression has been associated in liver grafts with prolonged cold storage times and rejection. By examining biomarkers of IRI including P-selectin by immunohistochemistry and/or quantitative PCR, liver histology and hepatic blood flow using established techniques, the goal of this study is to evaluate the feasibility of using these modalities for future studies of safety and efficacy.

YSPSL-0003 is an extension into 36 patients of the previous 12 patient pilot study YSPSL-0002 under an almost identical study protocol with extended inclusion criteria. Like YSPSL-0002, YSPSL-0003 is a single-center (UCLA), randomized, placebo-controlled, double-blind study. Patients are randomly assigned to either active study drug (Active group) or placebo (Control group) prior to transplantation. The active study drug dose includes both a 1 mg/kg IV infusion for the recipient and a 20 mg [approximately 0.27 mg/kg] as an ex vivo flush. The doses are administered via 2 separate infusions of study agent: one 20 mg dose into the portal vein of the liver prior to implantation as an ex vivo flush with Viaspan®; and the second infusion of 1 mg/kg intravenously into the recipient, when technically feasible, prior to the hepatic artery anastomosis. Placebo of a volume equivalent to active study drug is prepared for administration to the control group to help maintain the blind. Those patients that experience an intraoperative blood loss of >10 units, receive an additional 1 mg/kg IV infusion of study agent (or placebo equivalent) at the end of the transplant surgery. The Investigator/Sponsor is blinded to the treatment assignment for each patient. Randomization assignment is maintained by UCLA's clinical pharmacist.

Inclusion Criteria:

• Patient will be a recipient of a primary (first) ABO compatible cadaveric liver allograft
• Patient's age is less than 18 years
• Patient is not a recipient of a multivisceral transplant or simultaneous kidney transplant
• Patient has not undergone prior organ or cellular transplant of any type
• Patient has a Model for End Stage Liver Disease (MELD) score of ≤38
• Cold ischemia time (CIT) anticipated to be less than 14 hours
• Donor liver procured by UCLA liver team
• Veno-veno bypass is not planned to be used for the patient (e.g. no prior surgery or other factor that indicates a risk for excessive blood loss and therefore a need for veno-veno bypass +/- autologous recovery during surgery)
• For patients who are women of childbearing potential, patient has a negative pregnancy test (either urine or serum) within 48 hours prior to transplant
• Patient (male and female) is willing to use an acceptable form of birth control for at least 3 months post-treatment
• Patient is willing and able to sign informed consent.

Exclusion Criteria:

• Patient has a prior organ transplant of any type
• Patient has known allergic or intolerance reactions to human immune globulins, antibodies, or components of the formulation or known contraindication to administration of YSPSL
• Patient has an uncontrolled active infection (on antibiotics with controlled infection is not an exclusion)
• Patient has active Hepatitis B virus (HBV)/transplant for HBV related cirrhosis
• Patient has previously participated in this study or another study with YSPSL
• Patient has received investigational therapy within 90 days prior to the transplant procedure
• Patient has current drug or alcohol abuse or, in the opinion of the investigator, is at risk for poor compliance with the visits in this protocol (no drug testing required)
• Patient is a pregnant or nursing female, a female of childbearing potential planning to become pregnant within the duration of this study, or is not practicing birth control
• Patient is planned to receive a living donor liver transplant
• Patient lives >200 miles away or otherwise is not able to participate in study follow-up visits
• Donor body mass index >40
• Donor liver biopsy >40% macrosteatotic fat
• Donor age >70.