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The study investigates whether the use of eye movement recordings can provide a reliable diagnostic of previously undiagnosed mild traumatic brain injury (blast and impact) in Operations Enduring Freedom or Iraqi Freedom (OIF/OEF) veterans.
Eye movements are recorded for Operations Enduring Freedom or Iraqi Freedom (OIF/OEF) veterans with mild traumatic brain injury (mTBI) and compared to the eye movements of those without mTBI. By analyzing and characterizing the differences between the two groups, a diagnostic measure of mTBI through the use of eye movements can be developed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Control subjects with no Mild Traumatic Brain Injury (MTBI) and no Post-Traumatic Stress Disorder (PTSD) | ||
| MTBI | Subject with a diagnosis for Mild Traumatic Brain Injury (MTBI) |
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| Measure | Description | Time Frame |
|---|---|---|
| Stability of Fixation | The ability to keep eye position fixed on a visual target, measured by the distance between the target and eye fixation point averaged over 20 sec. | During eye movement recording session (20 sec). |
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Inclusion Criteria:
Exclusion Criteria:
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Adult betwenn 18 and 55 years old with and without a diagnosis of MTBI
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| Name | Affiliation | Role |
|---|---|---|
| Jonathan Jacobs, PhD | Louis Stokes VA Medical Center, Cleveland, OH | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Louis Stokes VA Medical Center, Cleveland, OH | Cleveland | Ohio | 44106 | United States |
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| ID | Title | Description |
|---|---|---|
| FG000 | Controls | Control Group - subjects with no Mild Traumatic Brain Injury (MTBI) |
| FG001 | MTBI | MTBI Group - subjects with diagnosed Mild Traumatic Brain Injury (MTBI) |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Controls | Control Group - subjects with no Mild Traumatic Brain Injury (MTBI) |
| BG001 | MTBI | MTBI Group - subjects with diagnosed Mild Traumatic Brain Injury (MTBI) |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Stability of Fixation | The ability to keep eye position fixed on a visual target, measured by the distance between the target and eye fixation point averaged over 20 sec. | Although there were 15 participants in the Control arm, data were only analyzed for a cohort of 11 that were age-matched to the MTBI arm participants. | Posted | Mean | Standard Deviation | degrees | During eye movement recording session (20 sec). |
|
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Controls | Control Group - subjects with no Mild Traumatic Brain Injury (MTBI) |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Jonathan Jacobs, PhD | Daroff-Dell'Osso Ocular Motility Laboratory | 216-791-3800 | 2947 | jxj24@case.edu |
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| BG002 | Total | Total of all reporting groups |
| Participants |
|
| Sex: Female, Male | Count of Participants | Participants |
|
|
|
| 0 |
| 15 |
| 0 |
| 15 |
| EG001 | MTBI | MTBI Group - subjects with diagnosed Mild Traumatic Brain Injury (MTBI) | 0 | 11 | 0 | 11 |
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| D006259 |
| Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |