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The purpose of this study is to determine whether the iTBS is an effective treatment of the negative symptoms of schizophrenia.
This study will evaluate whether the intermittent Theta Burst Stimulation (iTBS), a new high frequency TMS protocol is efficient in the treatment of the Negative Symptoms of schizophrenia.
Neuroimaging studies demonstrate that hypoactivity in the left dorsolateral prefrontal cortex (LDLPFC) was associated with negative symptoms.
The investigators hypothesize that iTBS applied to LDLPFC will improve negative symptoms and will improve activity of the LDLPFC measured with Magnetic Resonance Spectroscopy (MRS).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| active iTBS | Active Comparator | iTBS active intensity = 80%MT during 6 minutes. 20 sessions, 2 per day |
|
| sham iTBS | Placebo Comparator | iTBS placebo (placebo coil)with same parameters than active |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| active iTBS | Procedure | Intermittent Theta Burst Stimulation (iTBS) over Left dorsolateral prefrontal cortex. 80% MT, 20 sessions of 6 minutes, 2 per day |
|
| Measure | Description | Time Frame |
|---|---|---|
| Scale for the Assessment of Negative Symptoms (SANS) | before, after 2 weeks of treatment, and 3 times follow-up (1, 3 and 6 months) |
| Measure | Description | Time Frame |
|---|---|---|
| Neurochemical impact of treatment measured by 1H-MRS, DTI and resting MRI | 3 times, before treatment, immediatly after treatment and a last evaluation 3 months after |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Emmanuel Poulet, MD, PhD | Hopital Le Vinatier | Principal Investigator |
| JEROME BRUNELIN, PhD | Hopital le Vinatier | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital Le vinatier | Bron | France |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| sham iTBS | Procedure | iTBS placebo (placebo coil) |
|
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