Efficacy and Safety of Ethanol Lock Solution in Prevention of Catheter Related Bloodstream Infection for Patients Suffering Acute Renal Failure, and Hospitalized in Intensive Care Unit. A Multi-Center, Randomized, Versus Placebo, Double Blinded Clinical Trial

Efficacy and Safety of Ethanol Lock Solution in Prevention of Catheter Related Bloodstream Infection for Patients Suffering Acute Renal Failure, and Hospitalized in Intensive Care Unit. A Multi-Center, Randomized, Versus Placebo, Double Blinded Clinical Trial.

The primary objective of the study is to demonstrate the efficacy of 60% ethanol lock solution in preventing major catheter related infections in critically ill patients.

The primary objective of the study is to demonstrate the efficacy of 60% ethanol lock solution in preventing major catheter related infections in critically ill patients

Inclusion Criteria:

• Patients of both genders, over 18 years,
• Patients admitted in ICU
• Dialysis catheter insertion for renal replacement therapy
• At least two renal replacement therapy sessions
• Written informed consent
• Social security

Exclusion Criteria:

• Pregnant or breastfeeding women
• Patient requiring dialysis on arteriovenous fistula or permanent catheter
• Known allergy to ethanol
• Dialysis catheter covered or impregnated with antimicrobial agent
• Dialysis catheter insertion before ICU admission
• Single-lumen dialysis catheters
• Patient whose death is likely to occur within hours after admission to ICU