To determine the gastrointestinal safety of PL-2200 versus immediate-release aspirin by assessing endoscopic gastroduodenal mucosal injury at approved daily cardiac-protective doses of aspirin (325 mg) in normal healthy volunteers.

Inclusion Criteria:

• Subject is ≥50 to ≤75 years of age.
• Subject is healthy.
• Subject has a BMI between 20 and 32
• If female and of child bearing potential, subject has a negative pregnancy test and is not nursing.

Exclusion Criteria:

• Subject has abnormal screening/baseline laboratory parameters or endoscopic observations deemed clinically significant by the Investigator.
• Subject has an active Helicobacter pylori infection.
• Subject has a prior GI ulcer, bleeding, obstruction or perforation.
• Subject has taken aspirin or any aspirin containing product within the last 4 weeks, or a non-aspirin NSAID product within 2 weeks.
• Subject has taken any of the following medications within 2 weeks prior to enrollment: Any anti-platelet agents, anti-coagulants or selective serotonin reuptake inhibitors.
• Subject has used an investigational agent within the past 30 days.
• Subject has hypersensitivity or contraindications to aspirin, ibuprofen, or other NSAID.